Diversity of Mycobacterium tuberculosis Isolates from New Pulmonary Tuberculosis Cases in Addis Ababa, Ethiopia
Joint Authors
Yamuah, Lawrence
Jordan, Annemie M.
Walzl, Gerhard
Bekele, Yonas
Aseffa, Abraham
Mihret, Adane
Howe, Rawleigh
Loxton, Andre G.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Understanding the genetic diversity of Mycobacterium tuberculosis is needed for a better understanding of the epidemiology of TB and could have implications for the development of new diagnostics, drugs, and vaccines.
M.
tuberculosis isolates were characterized using spoligotyping and were compared with the SpoIDB4 database of the Pasteur Institute of Guadeloupe.
A total of 53 different patterns were identified among 192 isolates examined.
169 of the isolates were classified into one of the 33 shared SITs, whereas the remaining 23 corresponded to 20 orphan patterns.
54% of the isolates were ascribed to the T family, a family which has not been well defined to date.
Other prominent families were CAS, Haarlem, LAM, Beijing, and Unknown comprising 26%, 13%, 2.6%, 0.5%, and 2.1%, respectively.
Among HIV-positive patients, 10 patterns were observed among 25 isolates.
The T (38.5%), H (26.9%), and CAS (23.1%) families were the most common among HIV-positive individuals.
The diversity of the M.
tuberculosis strains found in this study is very high, and there was no difference in the distribution of families in HIV-positive and HIV-negative TB patients except the H family.
Tuberculosis transmission in Addis Ababa is due to only the modern M.
tuberculosis families (CAS, LAM, T, Beijing, Haarlem, and U).
American Psychological Association (APA)
Mihret, Adane& Bekele, Yonas& Loxton, Andre G.& Jordan, Annemie M.& Yamuah, Lawrence& Aseffa, Abraham…[et al.]. 2012. Diversity of Mycobacterium tuberculosis Isolates from New Pulmonary Tuberculosis Cases in Addis Ababa, Ethiopia. Tuberculosis Research and Treatment،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-505901
Modern Language Association (MLA)
Mihret, Adane…[et al.]. Diversity of Mycobacterium tuberculosis Isolates from New Pulmonary Tuberculosis Cases in Addis Ababa, Ethiopia. Tuberculosis Research and Treatment No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-505901
American Medical Association (AMA)
Mihret, Adane& Bekele, Yonas& Loxton, Andre G.& Jordan, Annemie M.& Yamuah, Lawrence& Aseffa, Abraham…[et al.]. Diversity of Mycobacterium tuberculosis Isolates from New Pulmonary Tuberculosis Cases in Addis Ababa, Ethiopia. Tuberculosis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-505901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-505901