Multifactorial Hypercalcemia and Literature Review on Primary Hyperparathyroidism Associated with Lymphoma

Joint Authors

Palma Diaz, Miguel Fernando
Yeh, Michael W.
Isorena, Jennifer P.
Korenman, Stanley G.
Maletkovic, Jelena

Source

Case Reports in Endocrinology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-03-05

Country of Publication

Egypt

No. of Pages

4

Main Subjects

Diseases

Abstract EN

The most common cause of hypercalcemia in hospitalized patients is malignancy.

Primary hyperparathyroidism most commonly causes hypercalcemia in the outpatient setting.

These two account for over 90% of all cases of hypercalcemia.

Hypercalcemia can be divided into PTH-mediated and PTH-independent variants.

Primary hyperparathyroidism, familial hypocalciuric hypercalcemia, familial hyperparathyroidism, and secondary hyperparathyroidism are PTH mediated.

The most common PTH-independent type of hypercalcemia is malignancy related.

Several mechanisms lead to hypercalcemia in malignancy-direct osteolysis by metastatic disease or, more commonly, production of humoral factors by the primary tumor also known as humoral hypercalcemia of malignancy that accounts for about 80% of malignancy-related hypercalcemia.

The majority of HHM is caused by tumor-produced parathyroid hormone-related protein and less frequently production of 1,25-dihydroxyvitamin D or parathyroid hormone by the tumor.

We report the rare case of a patient with hypercalcemia and diagnosed primary hyperparathyroidism.

The patient had persistent hypercalcemia after surgical removal of parathyroid adenoma with recorded significant decrease in PTH level.

After continued investigation it was found that the patient also had elevated 1,25-dihydroxyvitamin D and further studies confirmed a large spleen mass that was later confirmed to be a lymphoma.

This is a rare example of two concomitant causes of hypercalcemia requiring therapy.

American Psychological Association (APA)

Maletkovic, Jelena& Isorena, Jennifer P.& Palma Diaz, Miguel Fernando& Korenman, Stanley G.& Yeh, Michael W.. 2014. Multifactorial Hypercalcemia and Literature Review on Primary Hyperparathyroidism Associated with Lymphoma. Case Reports in Endocrinology،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-505991

Modern Language Association (MLA)

Maletkovic, Jelena…[et al.]. Multifactorial Hypercalcemia and Literature Review on Primary Hyperparathyroidism Associated with Lymphoma. Case Reports in Endocrinology No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-505991

American Medical Association (AMA)

Maletkovic, Jelena& Isorena, Jennifer P.& Palma Diaz, Miguel Fernando& Korenman, Stanley G.& Yeh, Michael W.. Multifactorial Hypercalcemia and Literature Review on Primary Hyperparathyroidism Associated with Lymphoma. Case Reports in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-505991

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-505991