Pistacia atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat
Joint Authors
Sanei, Mohammad Hossein
Javanmard, Shaghayegh Haghjooy
Baradaran Mahdavi, Mohammad Mehdi
Zandifar, Alireza
Zolfaghari, Behzad
Haghdoost, Faraidoon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objectives.
The aim of the present study was to evaluate the effect of Pistacia atlantica resin extract on the rat skin burn wound healing.
Methods.
Thirty-two Wistar rats were divided into four groups and treated by vehicle, 5%, 10%, and 20% concentration of Pistacia atlantica resin extract for 14 days (G1, G2, G3, and G4, resp.).
The efficacy of treatment was assessed based on reduction of burn wound size and histological and molecular characteristics.
Results.
α-Pinene (46.57%) was the main content of essential oil of resin.
There were no statistically significant differences between groups according to wound size analysis.
The mean histological wound healing scores were not statistically different.
Capillary counts of G2 and G3 were significantly higher than those of the G1 (P=0.042 and 0.032, resp.).
NO concentration in wound fluids on the 5th day of study was not significantly different between groups (P=0.468).
But bFGF concentration in G2 and G3 and PDGF concentration in G3 were significantly higher in comparison to G1 (P=0.043, 0.017, and 0.019, resp.).
Conclusion.
Our results revealed that Pistacia atlantica resin extract has a concentration-dependent effect on the healing of burn wounds after 14 days of treatment by increasing the concentration of bFGF and PDGF and also through improving the angiogenesis.
American Psychological Association (APA)
Haghdoost, Faraidoon& Baradaran Mahdavi, Mohammad Mehdi& Zandifar, Alireza& Sanei, Mohammad Hossein& Zolfaghari, Behzad& Javanmard, Shaghayegh Haghjooy. 2013. Pistacia atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506018
Modern Language Association (MLA)
Haghdoost, Faraidoon…[et al.]. Pistacia atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-506018
American Medical Association (AMA)
Haghdoost, Faraidoon& Baradaran Mahdavi, Mohammad Mehdi& Zandifar, Alireza& Sanei, Mohammad Hossein& Zolfaghari, Behzad& Javanmard, Shaghayegh Haghjooy. Pistacia atlantica Resin Has a Dose-Dependent Effect on Angiogenesis and Skin Burn Wound Healing in Rat. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506018
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506018