Antioxidant Activities of Plumbagin and Its Cu (II) Complex
Joint Authors
Tan, Mingxiong
Liang, Hong
Liu, Yancheng
Luo, Xujian
Chen, Zhenfeng
Source
Bioinorganic Chemistry and Applications
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Plumbagin and its Cu (II) complex [Cu (plumbagin)2]·H2O have been synthesized, and their antioxidant activities towards the inhibitory effect on DPPH free radical, reducing power, total antioxidant capacity, and inhibition on lipid peroxidation were investigated.
Plumbagin and its Cu (II) complex were found to exhibit scavenging activities on DPPH radical with the inhibitory rate of 41% and 24%, respectively.
The reducing power of plumbagin was outstanding at the concentrations of 1.0, 1.5, and 2.0 mg/mL, compared to Cu (II) complex and synthetic antioxidant 2,6-di-ter-butyl-4-methylphenol (BHT); the highest level reached 1.333 for plumbagin and 0.581 for Cu (II) complex.
Also, the inhibition on lipid peroxidation of plumbagin was higher than that of Cu (II) complex and BHT, 46.4% for plumbagin and 24.5% for Cu (II) complex.
The results give a strong impact for designing anticancer drugs, combined with their potential cytotoxic and antioxidant activities, which can be targeted selectively against cancer cells and increase their therapeutic index and additional advantages over other anticancer drugs.
American Psychological Association (APA)
Tan, Mingxiong& Liu, Yancheng& Luo, Xujian& Chen, Zhenfeng& Liang, Hong. 2011. Antioxidant Activities of Plumbagin and Its Cu (II) Complex. Bioinorganic Chemistry and Applications،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-506500
Modern Language Association (MLA)
Tan, Mingxiong…[et al.]. Antioxidant Activities of Plumbagin and Its Cu (II) Complex. Bioinorganic Chemistry and Applications No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-506500
American Medical Association (AMA)
Tan, Mingxiong& Liu, Yancheng& Luo, Xujian& Chen, Zhenfeng& Liang, Hong. Antioxidant Activities of Plumbagin and Its Cu (II) Complex. Bioinorganic Chemistry and Applications. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-506500
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506500