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Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants
Joint Authors
Picaud, Jean-Charles
Steghens, Jean-Paul
Haÿs, Stéphane
Cipierre, Cécile
Maucort-Boulch, Delphine
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Preterm infants (PT) are particularly exposed to oxidative stress (OS), and a blood-sparing marker, the malondialdehyde adduct to hemoglobin (MDA-Hb), may be useful to accurately assess OS-related neonatal morbidity.
In a prospective study, MDA-Hb concentrations were assessed in two groups of PT, one with and one without severe neonatal morbidity as estimated by a composite index of severe morbidity (ISM).
All PT born in a single tertiary care NICU (<32 weeks and birth weight <1500 g) were consecutively included.
MDA-Hb and blood glutathione (GSH) concentrations were measured by liquid chromatography-mass spectrometry during the first 6 weeks of life.
Linear regressions and a multilevel model were fitted to study the relationship between MDA-Hb or GSH and ISM.
Of the 83 PT (mean ± SD: 28.3±2 weeks, 1089±288 g), 21% presented severe neonatal morbidity.
In the multivariate model, MDA-Hb concentrations were significantly higher in the ISM+ group than in the ISM– group during the first 6 weeks of life (P=0.009).
No significant difference in GSH concentrations was observed between groups (P=0.180).
MDA-Hb is a marker of interest for estimating oxidative stress in PT and could be useful to evaluate the impact of strategies to improve perinatal outcomes.
American Psychological Association (APA)
Cipierre, Cécile& Haÿs, Stéphane& Maucort-Boulch, Delphine& Steghens, Jean-Paul& Picaud, Jean-Charles. 2013. Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506528
Modern Language Association (MLA)
Cipierre, Cécile…[et al.]. Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-506528
American Medical Association (AMA)
Cipierre, Cécile& Haÿs, Stéphane& Maucort-Boulch, Delphine& Steghens, Jean-Paul& Picaud, Jean-Charles. Adduct of Malondialdehyde to Hemoglobin : A New Marker of Oxidative Stress That Is Associated with Significant Morbidity in Preterm Infants. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-506528
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-506528