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The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection
Joint Authors
Maldonado, Perla D.
Santamaría, Abel
Santana, Ricardo A.
Colín-González, Ana L.
Silva-Islas, Carlos A.
Chánez-Cárdenas, Maria E.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Aged garlic extract (AGE) is an odorless garlic preparation containing S-allylcysteine (SAC) as its most abundant compound.
A large number of studies have demonstrated the antioxidant activity of AGE and SAC in both in vivo—in diverse experimental animal models associated to oxidative stress—and in vitro conditions—using several methods to scavenge reactive oxygen species or to induce oxidative damage.
Derived from these experiments, the protective effects of AGE and SAC have been associated with the prevention or amelioration of oxidative stress.
In this work, we reviewed different antioxidant mechanisms (scavenging of free radicals and prooxidant species, induction of antioxidant enzymes, activation of Nrf2 factor, inhibition of prooxidant enzymes, and chelating effects) involved in the protective actions of AGE and SAC, thereby emphasizing their potential use as therapeutic agents.
In addition, we highlight the ability of SAC to activate Nrf2 factor—a master regulator of the cellular redox state.
Here, we include original data showing the ability of SAC to activate Nrf2 factor in cerebral cortex.
Therefore, we conclude that the therapeutic properties of these molecules comprise cellular and molecular mechanisms at different levels.
American Psychological Association (APA)
Colín-González, Ana L.& Santana, Ricardo A.& Silva-Islas, Carlos A.& Chánez-Cárdenas, Maria E.& Santamaría, Abel& Maldonado, Perla D.. 2012. The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-507100
Modern Language Association (MLA)
Colín-González, Ana L.…[et al.]. The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-507100
American Medical Association (AMA)
Colín-González, Ana L.& Santana, Ricardo A.& Silva-Islas, Carlos A.& Chánez-Cárdenas, Maria E.& Santamaría, Abel& Maldonado, Perla D.. The Antioxidant Mechanisms Underlying the Aged Garlic Extract- and S-Allylcysteine-Induced Protection. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-507100
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507100