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Expression of CD44v6 and Its Association with Prognosis in Epithelial Ovarian Carcinomas
Joint Authors
Zhou, Dang-xia
Xue, Ya-hong
Liu, Yun-xia
Source
Pathology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-23
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The aim of this study was to evaluate CD44v6 protein expression and its prognostic value of CD44v6 in ovarian carcinoma.
The expression of CD44v6 was analyzed in 62 patients with ovarian carcinoma by immunohistochemical method.
The data obtained were analyzed by univariate and multivariate analyses.
The present study clearly demonstrates that tumor tissues from 41 (66.1%) patients showed positive expression with CD44v6.
The expression of CD44v6 was significantly correlated with histological type, FIGO stage and histological grade of ovarian carcinomas.
Concerning the prognosis, the survival period of patients with CD44v6 positive was shorter than that of patients with CD44v6 negative (36.6% versus 66.7%, 5-year survival, P<0.05).
Univariate analysis showed that CD44v6 expression, histological type, FIGO stage and histological grade were associated with 5-year survival, and CD44v6 expression was associated with histological type, FIGO stage and histological grade and 5-year survival.
In multivariate analysis, using the COX-regression model, CD44v6 expression was important prognostic factor.
In conclusion, these results suggest that CD44v6 may be related to histological type, FIGO stage and histological grade of ovarian carcinomas, and CD44v6 may be an important molecular marker for poor prognosis in ovarian carcinomas.
American Psychological Association (APA)
Zhou, Dang-xia& Liu, Yun-xia& Xue, Ya-hong. 2012. Expression of CD44v6 and Its Association with Prognosis in Epithelial Ovarian Carcinomas. Pathology Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-507206
Modern Language Association (MLA)
Zhou, Dang-xia…[et al.]. Expression of CD44v6 and Its Association with Prognosis in Epithelial Ovarian Carcinomas. Pathology Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-507206
American Medical Association (AMA)
Zhou, Dang-xia& Liu, Yun-xia& Xue, Ya-hong. Expression of CD44v6 and Its Association with Prognosis in Epithelial Ovarian Carcinomas. Pathology Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-507206
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507206