![](/images/graphics-bg.png)
Cytokine Pattern of T Lymphocytes in Acute Schistosomiasis mansoni Patients following Treated Praziquantel Therapy
Joint Authors
Soares Silveira, Alda Maria
Fernandes Costa-Silva, Matheus
Cardoso de Oliveira Silveira, Amanda
Alves Oliveira-Fraga, Lúcia
Martins-Filho, Olindo Assis
Silveira-Lemos, Denise
Barbosa Alvarez, Maria Carolina
Teixeira-Carvalho, Andrea
Corrêa-Oliveira, Rodrigo
Gazzinelli, Giovanni
Azevedo Batista, Mauricio
Source
Journal of Parasitology Research
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Acute schistosomiasis is associated with a primary exposure and is more commonly seen in nonimmune individuals traveling through endemic regions.
In this study, we have focused on the cytokine profile of T lymphocytes evaluated in circulating leukocytes of acute Schistosomiasis mansoni-infected patients (ACT group) before and after praziquantel treatment (ACT-TR group).
Our data demonstrated increased values of total leukocytes, eosinophils, and monocytes in both groups.
Interestingly, we have observed that patients treated with praziquantel showed increased values of lymphocytes as compared with noninfected group (NI) or ACT groups.
Furthermore, a decrease of neutrophils in ACT-TR was observed when compared to ACT group.
Analyses of short-term in vitro whole blood stimulation demonstrated that, regardless of the presence of soluble Schistosoma mansoni eggs antigen (SEA), increased synthesis of IFN-γ and IL-4 by T-cells was observed in the ACT group.
Analyses of cytokine profile in CD8 T cells demonstrated higher percentage of IFN-γ and IL-4 cells in both ACT and ACT-TR groups apart from increased percentage of IL-10 cells only in the ACT group.
This study is the first one to point out the relevance of CD8 T lymphocytes in the immune response induced during the acute phase of schistosomiasis.
American Psychological Association (APA)
Silveira-Lemos, Denise& Fernandes Costa-Silva, Matheus& Cardoso de Oliveira Silveira, Amanda& Azevedo Batista, Mauricio& Alves Oliveira-Fraga, Lúcia& Soares Silveira, Alda Maria…[et al.]. 2013. Cytokine Pattern of T Lymphocytes in Acute Schistosomiasis mansoni Patients following Treated Praziquantel Therapy. Journal of Parasitology Research،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-507281
Modern Language Association (MLA)
Silveira-Lemos, Denise…[et al.]. Cytokine Pattern of T Lymphocytes in Acute Schistosomiasis mansoni Patients following Treated Praziquantel Therapy. Journal of Parasitology Research No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-507281
American Medical Association (AMA)
Silveira-Lemos, Denise& Fernandes Costa-Silva, Matheus& Cardoso de Oliveira Silveira, Amanda& Azevedo Batista, Mauricio& Alves Oliveira-Fraga, Lúcia& Soares Silveira, Alda Maria…[et al.]. Cytokine Pattern of T Lymphocytes in Acute Schistosomiasis mansoni Patients following Treated Praziquantel Therapy. Journal of Parasitology Research. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-507281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507281