![](/images/graphics-bg.png)
A Decade of Experience Using mTor Inhibitors in Liver Transplantation
Joint Authors
Kaplan, Maria
Campsen, Jeffrey
Kam, Igal
Mandell, M. Susan
Zimmerman, Michael A.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Some studies suggest that Sirolimus (SRL) is associated with an increased risk of death in liver transplant recipients compared to treatment with calcineurin inhibitors (CNIs).
We compared patients who received SRL or CNI in the first year after liver transplant.
Our database included 688 patients who received a liver transplant.
The patients were divided into groups.
(1) CNI + MPS (mycophenolate sodium) at time of discharge.
(2) CNI + MPS at time of discharge; SRL was added within the first 6 months and continued through the first year.
(3) CNI + MPS at time of discharge; SRL was added within the first 6 months and discontinued before the first year.
(4) SRL as primary immunosuppression.
(5) SRL as primary immunosuppression and discontinued before the first year.
We used mortality and graft loss as the primary measures of outcome.
We also quantified renal function using the change in glomerular filtration rate (GFR), the presence of biopsy proven acute cellular reject (ACR), and steroid-resistant rejection (SRR).
There were no significant differences in mortality or graft loss.
There was no difference in patient or graft survival.
Patients that received SRL as primary immunosuppression had 50% less rejection compared to controls.
American Psychological Association (APA)
Campsen, Jeffrey& Zimmerman, Michael A.& Mandell, M. Susan& Kaplan, Maria& Kam, Igal. 2011. A Decade of Experience Using mTor Inhibitors in Liver Transplantation. Journal of Transplantation،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-507564
Modern Language Association (MLA)
Campsen, Jeffrey…[et al.]. A Decade of Experience Using mTor Inhibitors in Liver Transplantation. Journal of Transplantation No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-507564
American Medical Association (AMA)
Campsen, Jeffrey& Zimmerman, Michael A.& Mandell, M. Susan& Kaplan, Maria& Kam, Igal. A Decade of Experience Using mTor Inhibitors in Liver Transplantation. Journal of Transplantation. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-507564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507564