Incidence of Pregnancy after Initiation of Antiretroviral Therapy in South Africa : A Retrospective Clinical Cohort Analysis
Joint Authors
Westreich, Daniel J.
Majuba, Pappie
MacDonald, Pippa
Maskew, Mhairi
Jaffray, Imogen
Rubel, Dennis
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Little is known about rates of incident pregnancy among HIV-positive women initiating highly active antiretroviral therapy (HAART).
Methods.
We conducted a retrospective clinical cohort study among therapy-naïve women ages 18–45 initiating HAART between 1 April 2004 and 30 September 2009 at an adult HAART clinic in Johannesburg, South Africa.
We used Poisson regression to characterize rates and rate ratios of pregnancy.
Results.
We evaluated 5,996 women who experienced 727 pregnancies during 14,095 person-years at risk.
The overall rate of pregnancy was 5.2 per 100 person-years (95% confidence limits [CL] 4.8, 5.5).
By six years, cumulative incidence of first pregnancy was 22.9% (95% CL 20.6%, 25.4%); among women ages 18–25 at HAART initiation, cumulative incidence was 52.2% (95% CL 35.0%, 71.8%).
The strongest predictor of incidence of pregnancy was age, with women 18–25 having 13.2 times the rate of pregnancy of women ages 40–45 in adjusted analysis.
CD4 counts below 100 and worse adherence to HAART were associated with lower rates of incident pregnancy.
Conclusions.
Women experience high rates of incident pregnancy after HAART initiation.
Understanding which women are most likely to experience pregnancy will help planning and future efforts to understand the implications of pregnancy for response to HAART.
American Psychological Association (APA)
Westreich, Daniel J.& Maskew, Mhairi& Rubel, Dennis& MacDonald, Pippa& Jaffray, Imogen& Majuba, Pappie. 2012. Incidence of Pregnancy after Initiation of Antiretroviral Therapy in South Africa : A Retrospective Clinical Cohort Analysis. Infectious Diseases in Obstetrics and Gynecology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-507918
Modern Language Association (MLA)
Westreich, Daniel J.…[et al.]. Incidence of Pregnancy after Initiation of Antiretroviral Therapy in South Africa : A Retrospective Clinical Cohort Analysis. Infectious Diseases in Obstetrics and Gynecology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-507918
American Medical Association (AMA)
Westreich, Daniel J.& Maskew, Mhairi& Rubel, Dennis& MacDonald, Pippa& Jaffray, Imogen& Majuba, Pappie. Incidence of Pregnancy after Initiation of Antiretroviral Therapy in South Africa : A Retrospective Clinical Cohort Analysis. Infectious Diseases in Obstetrics and Gynecology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-507918
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507918