Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction
Joint Authors
O’Meara, Eileen
Touyz, Rhian M.
Racine, Normand
Ducharme, Anique
Chabot-Blanchet, Malorie
Gayda, Mathieu
White, Michel
de Denus, Simon
Rouleau, Jean Lucien
Myers, Jonathan N.
Harel, François
Lavoie, Joel
Sirois, Martin G.
Vitiello, Damien
Source
International Journal of Vascular Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Changes in cardiopulmonary reserve and biomarkers related to wall stress, inflammation, and oxidative stress concomitantly with the evaluation of peripheral arterial blood flow have not been investigated in patients with heart failure with preserved ejection fraction (HFpEF) compared with healthy subjects (CTL).
Methods and Results.
Eighteen HFpEF patients and 14 CTL were recruited.
Plasma levels of inflammatory and oxidative stress biomarkers were measured at rest.
Brain natriuretic peptide (BNP) was measured at rest and peak exercise.
Cardiopulmonary reserve was assessed using an exercise protocol with gas exchange analyses.
Peripheral arterial blood flow was determined by strain gauge plethysmography.
Peak VO2 (12.0±0.4 versus 19.1±1.1 mL/min/kg, P<0.001) and oxygen uptake efficiency slope (1.55±0.12 versus 2.06±0.14, P<0.05) were significantly decreased in HFpEF patients compared with CTL.
BNP at rest and following stress, C-reactive-protein, interleukin-6, and TBARS were significantly elevated in HFpEF.
Both basal and posthyperemic arterial blood flow were not significantly different between the HFpEF patients and CTL.
Conclusions.
HFpEF exhibits a severe reduction in cardiopulmonary reserve and oxygen uptake efficiency concomitantly with an elevation in a broad spectrum of biomarkers confirming an inflammatory and prooxidative status in patients with HFpEF.
American Psychological Association (APA)
Vitiello, Damien& Harel, François& Touyz, Rhian M.& Sirois, Martin G.& Lavoie, Joel& Myers, Jonathan N.…[et al.]. 2014. Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction. International Journal of Vascular Medicine،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-507939
Modern Language Association (MLA)
Vitiello, Damien…[et al.]. Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction. International Journal of Vascular Medicine No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-507939
American Medical Association (AMA)
Vitiello, Damien& Harel, François& Touyz, Rhian M.& Sirois, Martin G.& Lavoie, Joel& Myers, Jonathan N.…[et al.]. Changes in Cardiopulmonary Reserve and Peripheral Arterial Function Concomitantly with Subclinical Inflammation and Oxidative Stress in Patients with Heart Failure with Preserved Ejection Fraction. International Journal of Vascular Medicine. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-507939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507939