Outcome of Combined Hepatocellular and Cholangiocarcinoma of the Liver
Joint Authors
Kessinger, Anne
Wang, Jue
Wang, Fen Wei
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The objective of this study was to examine the epidemiology, natural history, and prognostic factors of combined hepatocellular and cholangiocarcinoma (cHCC-CC) using population-based registry.
Methods.
The Surveillance, Epidemiology, and End Results Program database (1973–2004) was used to identify cases of cHCC-CC.
Multivariable logistic regression was used to evaluate factors associated with cancer-directed surgery (CDS).
The influence of CDS on cancer specific survival was evaluated using Kaplan-Meier curves and Cox proportional hazards modeling.
Results.
A total of 380 cases of cHCC-CC were identified, which account for approximately 0.87% of primary liver tumors.
Of all patients, 69.8% of patients had regional or distant stage; 65.6% of patients had poorly or undifferentiated histology.
Only 44.9% of patients with localized disease, received CDS.
By logistic regression analysis, being widowed, advanced stage, and earlier diagnosis year were associated with lower rate of utilization of CDS.
In multivariate analysis, tumor stage, receipt of CDS, and recent year of diagnosis were found to be significant predictors for cancer-specific survival.
Conclusions.
Patients with localized cHCC-CC who are selected for CDS were strongly associated with improved survival.
However, many patients with localized tumors did not receive potentially curative cancer-directed surgery.
Further study is warranted to address the barriers to the delivery of appropriate care to these patients.
American Psychological Association (APA)
Wang, Jue& Wang, Fen Wei& Kessinger, Anne. 2010. Outcome of Combined Hepatocellular and Cholangiocarcinoma of the Liver. Journal of Oncology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-507949
Modern Language Association (MLA)
Wang, Jue…[et al.]. Outcome of Combined Hepatocellular and Cholangiocarcinoma of the Liver. Journal of Oncology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-507949
American Medical Association (AMA)
Wang, Jue& Wang, Fen Wei& Kessinger, Anne. Outcome of Combined Hepatocellular and Cholangiocarcinoma of the Liver. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-507949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-507949