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Patterns of Antimicrobial Resistance in the Causative Organisms of Spontaneous Bacterial Peritonitis : A Single Centre, Six-Year Experience of 1981 Samples
Joint Authors
Zare, Elham
Hafezi-Nejad, Nima
Abdollahi, Alireza
Sheikhbahaei, Sara
Source
International Journal of Hepatology
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-20
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background/Aims.
Spontaneous bacterial peritonitis (SBP) is one of the leading causes of morbidity and mortality in patients with cirrhosis.
This study aims to determine the microbial agents of SBP and the pattern of antibiotic resistance, in a large number of ascitic samples.
Methodology.
In a cross-sectional, single center, hospital based study, 1981 consecutive ascitic fluid samples were recruited from 2005 to 2011.
Samples were dichotomized into three-year periods, in order to assess the trend of resistance to the first-line empirical antibiotics.
Results.
SBP was found in 482 (24.33%) of samples, of which 314 (65.15%) were culture positive.
The most prevalent isolated pathogen was E.
coli (33.8%), followed by staphylococcus aureus (8.9%) and Enterococcus (8.6%).
No significant changes in the proportion of gram-negative/gram-positive infections occurred during this period.
A percentage of resistant strains to cefotaxime (62.5%, 85.7%), ceftazidim (73%, 82.1%), ciprofloxacin (30, 59.8%), ofloxacin (36.8%, 50%), and oxacilin (35%, 51.6%) were significantly increased.
E.
coli was most sensitive to imipenem, piperacillin-tazobactam, amikacin, ceftizoxime, and gentamicin.
Conclusions.
The microbial aetiology of SBP remains relatively constant.
However, the resistance rate especially to the first-line recommended antibiotics was significantly increased.
This pattern must be watched closely and taken into account in empirical antibiotic treatment.
American Psychological Association (APA)
Sheikhbahaei, Sara& Abdollahi, Alireza& Hafezi-Nejad, Nima& Zare, Elham. 2014. Patterns of Antimicrobial Resistance in the Causative Organisms of Spontaneous Bacterial Peritonitis : A Single Centre, Six-Year Experience of 1981 Samples. International Journal of Hepatology،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-508001
Modern Language Association (MLA)
Sheikhbahaei, Sara…[et al.]. Patterns of Antimicrobial Resistance in the Causative Organisms of Spontaneous Bacterial Peritonitis : A Single Centre, Six-Year Experience of 1981 Samples. International Journal of Hepatology No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-508001
American Medical Association (AMA)
Sheikhbahaei, Sara& Abdollahi, Alireza& Hafezi-Nejad, Nima& Zare, Elham. Patterns of Antimicrobial Resistance in the Causative Organisms of Spontaneous Bacterial Peritonitis : A Single Centre, Six-Year Experience of 1981 Samples. International Journal of Hepatology. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-508001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508001