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Renal Development and Blood Pressure in Offspring from Dams Submitted to High-Sodium Intake during Pregnancy and Lactation
Joint Authors
Balbi, Ana Paula C.
Francescato, Heloísa D. C.
Coimbra, Terezila M.
Marin, Evelyn C. S.
Costa, Roberto S.
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-05
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Exposure to an adverse environment in utero appears to programme physiology and metabolism permanently, with long-term consequences for health of the fetus or offspring.
It was observed that the offspring from dams submitted to high-sodium intake during pregnancy present disturbances in renal development and in blood pressure.
These alterations were associated with lower plasma levels of angiotensin II (AII) and changes in renal AII receptor I (AT1) and mitogen-activated protein kinase (MAPK) expressions during post natal kidney development.
Clinical and experimental evidence show that the renin-angiotensin system (RAS) participates in renal development.
Many effects of AII are mediated through MAPK pathways.
Extracellular signal-regulated protein kinases (ERKs) play a pivotal role in cellular proliferation and differentiation.
In conclusion, high-sodium intake during pregnancy and lactation can provoke disturbances in renal development in offspring leading to functional and structural alterations that persist in adult life.
These changes can be related at least in part with the decrease in RAS activity considering that this system has an important role in renal development.
American Psychological Association (APA)
Coimbra, Terezila M.& Francescato, Heloísa D. C.& Balbi, Ana Paula C.& Marin, Evelyn C. S.& Costa, Roberto S.. 2012. Renal Development and Blood Pressure in Offspring from Dams Submitted to High-Sodium Intake during Pregnancy and Lactation. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-508122
Modern Language Association (MLA)
Coimbra, Terezila M.…[et al.]. Renal Development and Blood Pressure in Offspring from Dams Submitted to High-Sodium Intake during Pregnancy and Lactation. International Journal of Nephrology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-508122
American Medical Association (AMA)
Coimbra, Terezila M.& Francescato, Heloísa D. C.& Balbi, Ana Paula C.& Marin, Evelyn C. S.& Costa, Roberto S.. Renal Development and Blood Pressure in Offspring from Dams Submitted to High-Sodium Intake during Pregnancy and Lactation. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-508122
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-508122