Adsorption and Desorption of Bioactive Proteins on Hydroxyapatite for Protein Delivery Systems
Joint Authors
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Hydroxyapatite (HA) is a precursor of bone and has been studied as a biomaterial.
We attempted HA to apply to protein delivery systems.
In this study, the association and dissociation properties of two types of bioactive proteins, cytochrom c and insulin, to HA were investigated.
Cytochrom c was less associated with HA than insulin, which was easily released from it.
However, the release of insulin from HA was slow.
Insulin was released from HA at pH 7.4 more rapidly than at pH 3.
The association and dissociation properties might be influenced by the size, solubility and net charge of protein.
HA is a potential protein carrier with controlled release.
American Psychological Association (APA)
Kojima, Chie& Watanabe, Kenji. 2012. Adsorption and Desorption of Bioactive Proteins on Hydroxyapatite for Protein Delivery Systems. Journal of Drug Delivery،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-509265
Modern Language Association (MLA)
Kojima, Chie& Watanabe, Kenji. Adsorption and Desorption of Bioactive Proteins on Hydroxyapatite for Protein Delivery Systems. Journal of Drug Delivery No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-509265
American Medical Association (AMA)
Kojima, Chie& Watanabe, Kenji. Adsorption and Desorption of Bioactive Proteins on Hydroxyapatite for Protein Delivery Systems. Journal of Drug Delivery. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-509265
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509265
