Endocrine and Metabolic Signaling in Retroperitoneal White Adipose Tissue Remodeling during Cold Acclimation
Joint Authors
Korac, Aleksandra
Markelic, Milica
Stancic, Ana
Velickovic, Ksenija
Vucetic, Milica
Buzadzic, Biljana
Golic, Igor
Otasevic, Vesna
Jankovic, Aleksandra
Korac, Bato
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The expression profiles of adiponectin, resistin, 5′-AMP-activated protein kinase α (AMPKα), hypoxia-inducible factor-1α (HIF-1α), and key enzymes of glucose and fatty acid metabolism and oxidative phosphorylation in rat retroperitoneal white adipose tissue (RpWAT) during 45-day cold acclimation were examined.
After transient suppression on day 1, adiponectin protein level increased following sustained cold exposure.
In parallel, on day 1, the protein level of HIF-1α was strongly induced and AMPKα suppressed, while afterwards the reverse was seen.
What is more, after an initial decrease on day 1, a sequential increase in pyruvate dehydrogenase, acyl-CoA dehydrogenase, cytochrome c oxidase, and ATP synthase and a decrease in acetyl-CoA carboxylase (from day 3) were observed.
Similar to adiponectin, protein level of resistin showed a biphasic profile: it increased after days 1, 3, and 7 and decreased below the control after 21 days of cold-acclimation.
In summary, the data suggest that adiponectin and resistin are important integrators of RpWAT metabolic response and roles it plays during cold acclimation.
It seems that AMPKα mediate adiponectin effects on metabolic remodeling RpWAT during cold acclimation.
American Psychological Association (APA)
Jankovic, Aleksandra& Korac, Aleksandra& Buzadzic, Biljana& Otasevic, Vesna& Stancic, Ana& Vucetic, Milica…[et al.]. 2013. Endocrine and Metabolic Signaling in Retroperitoneal White Adipose Tissue Remodeling during Cold Acclimation. Journal of Obesity،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-509674
Modern Language Association (MLA)
Jankovic, Aleksandra…[et al.]. Endocrine and Metabolic Signaling in Retroperitoneal White Adipose Tissue Remodeling during Cold Acclimation. Journal of Obesity No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-509674
American Medical Association (AMA)
Jankovic, Aleksandra& Korac, Aleksandra& Buzadzic, Biljana& Otasevic, Vesna& Stancic, Ana& Vucetic, Milica…[et al.]. Endocrine and Metabolic Signaling in Retroperitoneal White Adipose Tissue Remodeling during Cold Acclimation. Journal of Obesity. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-509674
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509674