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Caudate Nucleus Volume Mediates the Link between Cardiorespiratory Fitness and Cognitive Flexibility in Older Adults
Joint Authors
Gothe, Neha P.
Basak, Chandramallika
Wojcicki, Thomas R.
Kramer, Arthur F.
Verstynen, Timothy D.
Miller, Destiny L.
Szabo, Amanda
Fanning, Jason
Prakash, Ruchika Shaurya
Olson, Erin A.
McAuley, Edward
Voss, Michelle W.
Lynch, Brighid
Chaddock, Laura
Erickson, Kirk I.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
The basal ganglia play a central role in regulating the response selection abilities that are critical for mental flexibility.
In neocortical areas, higher cardiorespiratory fitness levels are associated with increased gray matter volume, and these volumetric differences mediate enhanced cognitive performance in a variety of tasks.
Here we examine whether cardiorespiratory fitness correlates with the volume of the subcortical nuclei that make up the basal ganglia and whether this relationship predicts cognitive flexibility in older adults.
Structural MRI was used to determine the volume of the basal ganglia nuclei in a group of older, neurologically healthy individuals (mean age 66 years, N=179).
Measures of cardiorespiratory fitness (VO2max), cognitive flexibility (task switching), and attentional control (flanker task) were also collected.
Higher fitness levels were correlated with higher accuracy rates in the Task Switching paradigm.
In addition, the volume of the caudate nucleus, putamen, and globus pallidus positively correlated with Task Switching accuracy.
Nested regression modeling revealed that caudate nucleus volume was a significant mediator of the relationship between cardiorespiratory fitness, and task switching performance.
These findings indicate that higher cardiorespiratory fitness predicts better cognitive flexibility in older adults through greater grey matter volume in the dorsal striatum.
American Psychological Association (APA)
Verstynen, Timothy D.& Lynch, Brighid& Miller, Destiny L.& Voss, Michelle W.& Prakash, Ruchika Shaurya& Chaddock, Laura…[et al.]. 2012. Caudate Nucleus Volume Mediates the Link between Cardiorespiratory Fitness and Cognitive Flexibility in Older Adults. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509825
Modern Language Association (MLA)
Verstynen, Timothy D.…[et al.]. Caudate Nucleus Volume Mediates the Link between Cardiorespiratory Fitness and Cognitive Flexibility in Older Adults. Journal of Aging Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-509825
American Medical Association (AMA)
Verstynen, Timothy D.& Lynch, Brighid& Miller, Destiny L.& Voss, Michelle W.& Prakash, Ruchika Shaurya& Chaddock, Laura…[et al.]. Caudate Nucleus Volume Mediates the Link between Cardiorespiratory Fitness and Cognitive Flexibility in Older Adults. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-509825
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509825