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To Bind or to Let Loose : Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium
Joint Authors
Karachiwala, Hatim
Noviasky, John
Lehmann, David F.
Sandal, Shaifali
Wang, Dongliang
Elliott, William C.
Source
International Journal of Nephrology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The use of sodium polystyrene sulfonate in decreasing serum potassium has recently been questioned due to the lack of documented effectiveness.
Methods.
A retrospective cohort analysis of all hospitalized patients who received sodium polystyrene sulfonate over four months was performed.
The change in serum potassium was noted over a period of 24 hours.
Patients who received any other form of potassium-altering drug or treatment were excluded.
Results.
The administration of sodium polystyrene sulfonate reduced serum potassium by 16.7% (P<0.001) as compared to the baseline serum potassium over a period of 24 hours.
During this same time, no change in serum creatinine was identified (P=0.73).
In addition, there was no correlation between potassium and creatinine change (r2 = 0.0004 and P=0.99).
Patients with higher initial serum potassium (≥5.6 mEq/L) reduced their potassium concentration 4% more than those with initial serum potassium of <5.6 mEq/L; however, this reduction did not reach statistical significance (P=0.32).
There was no significant difference in the effectiveness of 15 gm and 30 gm resin preparation (P=0.54).
Thirteen deaths were noted in our cohort, of which one death was due to ischemic colitis.
Conclusion.
We conclude that sodium polystyrene sulfonate is effective in lowering serum potassium.
American Psychological Association (APA)
Sandal, Shaifali& Karachiwala, Hatim& Noviasky, John& Wang, Dongliang& Elliott, William C.& Lehmann, David F.. 2012. To Bind or to Let Loose : Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium. International Journal of Nephrology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-509904
Modern Language Association (MLA)
Sandal, Shaifali…[et al.]. To Bind or to Let Loose : Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium. International Journal of Nephrology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-509904
American Medical Association (AMA)
Sandal, Shaifali& Karachiwala, Hatim& Noviasky, John& Wang, Dongliang& Elliott, William C.& Lehmann, David F.. To Bind or to Let Loose : Effectiveness of Sodium Polystyrene Sulfonate in Decreasing Serum Potassium. International Journal of Nephrology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-509904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-509904