Clinical Predictors of Mortality in Adults with Intellectual Disabilities with and without Down Syndrome
Joint Authors
Bennett, Vernon
Thorpe, Lilian
Pahwa, Punam
Kirk, Andrew
Nanson, Josephine
Source
Current Gerontology and Geriatrics Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Mood, baseline functioning, and cognitive abilities as well as psychotropic medications may contribute to mortality in adults with and without Down Syndrome (DS).
Methods.
Population-based (nonclinical), community-dwelling adults with intellectual disabilities (IDs) were recruited between 1995 and 2000, assessed individually for 1–4 times, and then followed by yearly phone calls.
Results.
360 participants (116 with DS and 244 without DS) were followed for an average of 12.9 years (range 0–16.1 years as of July 2011).
108 people died during the course of the followup, 65 males (31.9% of all male participants) and 43 females (27.6% of all female participants).
Cox proportional hazards modeling showed that baseline practical skills, seizures, anticonvulsant use, depressive symptoms, and cognitive decline over the first six years all significantly contributed to mortality, as did a diagnosis of DS, male gender, and higher age at study entry.
Analysis stratified by DS showed interesting differences in mortality predictors.
Conclusion.
Although adults with DS have had considerable improvements in life expectancy over time, they are still disadvantaged compared to adults with ID without DS.
Recognition of potentially modifiable factors such as depression may decrease this risk.
American Psychological Association (APA)
Thorpe, Lilian& Pahwa, Punam& Bennett, Vernon& Kirk, Andrew& Nanson, Josephine. 2012. Clinical Predictors of Mortality in Adults with Intellectual Disabilities with and without Down Syndrome. Current Gerontology and Geriatrics Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-510238
Modern Language Association (MLA)
Thorpe, Lilian…[et al.]. Clinical Predictors of Mortality in Adults with Intellectual Disabilities with and without Down Syndrome. Current Gerontology and Geriatrics Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-510238
American Medical Association (AMA)
Thorpe, Lilian& Pahwa, Punam& Bennett, Vernon& Kirk, Andrew& Nanson, Josephine. Clinical Predictors of Mortality in Adults with Intellectual Disabilities with and without Down Syndrome. Current Gerontology and Geriatrics Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-510238
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510238