Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints
Joint Authors
Brown, Jesse A.
Bookheimer, Susan Y.
Henning, Susanne M.
Renner, Brian A.
Ekstrom, Arne
Moody, Teena
Jones, Mike
Li, Zhaoping
Small, Gary W.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Despite increasing emphasis on the potential of dietary antioxidants in preventing memory loss and on diet as a precursor of neurological health, rigorous studies investigating the cognitive effects of foods and their components are rare.
Recent animal studies have reported memory and other cognitive benefits of polyphenols, found abundantly in pomegranate juice.
We performed a preliminary, placebo-controlled randomized trial of pomegranate juice in older subjects with age-associated memory complaints using memory testing and functional brain activation (fMRI) as outcome measures.
Thirty-two subjects (28 completers) were randomly assigned to drink 8 ounces of either pomegranate juice or a flavor-matched placebo drink for 4 weeks.
Subjects received memory testing, fMRI scans during cognitive tasks, and blood draws for peripheral biomarkers before and after the intervention.
Investigators and subjects were all blind to group membership.
After 4 weeks, only the pomegranate group showed a significant improvement in the Buschke selective reminding test of verbal memory and a significant increase in plasma trolox-equivalent antioxidant capacity (TEAC) and urolithin A-glucuronide.
Furthermore, compared to the placebo group, the pomegranate group had increased fMRI activity during verbal and visual memory tasks.
While preliminary, these results suggest a role for pomegranate juice in augmenting memory function through task-related increases in functional brain activity.
American Psychological Association (APA)
Bookheimer, Susan Y.& Renner, Brian A.& Ekstrom, Arne& Li, Zhaoping& Henning, Susanne M.& Brown, Jesse A.…[et al.]. 2013. Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-510372
Modern Language Association (MLA)
Bookheimer, Susan Y.…[et al.]. Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-510372
American Medical Association (AMA)
Bookheimer, Susan Y.& Renner, Brian A.& Ekstrom, Arne& Li, Zhaoping& Henning, Susanne M.& Brown, Jesse A.…[et al.]. Pomegranate Juice Augments Memory and fMRI Activity in Middle-Aged and Older Adults with Mild Memory Complaints. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-510372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510372