Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection
Joint Authors
Bitencourt, Claudia da Silva
Pereira, Priscilla Aparecida Tartari
Sadikot, Ruxana T.
Peres-Buzalaf, Camila
Faccioli, Lúcia Helena
Ramos, Simone Gusmão
Secatto, Adriana
Nicolete, Roberto
Trindade, Bruno Caetano
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Prostaglandins act as mediators of inflammation and, similar to cytokines, function as immune modulators during innate and adaptive immune responses.
Therefore, using a pharmacological inhibitor, celecoxib, we investigated the role of prostaglandins in host defense against Histoplasma capsulatum infection in C57BL/6 mice.
Our results showed that treatment with celecoxib inhibited cyclooxygenase 2, reduced the total fungal burden, and reduced the concentration of PGE2, cytokines, lymphocytes, neutrophils, and mononuclear cells in the bronchoalveolar space and lung parenchyma.
In addition, celecoxib treatment increased the synthesis of nitric oxide, IFN-γ, LTB4, and the phagocytic capacity of alveolar macrophages.
Moreover, celecoxib treatment increased the survival of mice after infection with a lethal inoculum of H.
capsulatum.
These results suggest that prostaglandins alter the host immune response and play an important role in the pathogenesis of histoplasmosis.
Thus, the inhibition of prostaglandins could be a valuable immunomodulatory strategy and antifungal therapy for histoplasmosis treatment.
American Psychological Association (APA)
Pereira, Priscilla Aparecida Tartari& Trindade, Bruno Caetano& Secatto, Adriana& Nicolete, Roberto& Peres-Buzalaf, Camila& Ramos, Simone Gusmão…[et al.]. 2013. Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-510798
Modern Language Association (MLA)
Pereira, Priscilla Aparecida Tartari…[et al.]. Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection. Mediators of Inflammation No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-510798
American Medical Association (AMA)
Pereira, Priscilla Aparecida Tartari& Trindade, Bruno Caetano& Secatto, Adriana& Nicolete, Roberto& Peres-Buzalaf, Camila& Ramos, Simone Gusmão…[et al.]. Celecoxib Improves Host Defense through Prostaglandin Inhibition during Histoplasma capsulatum Infection. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-510798
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510798