Endometrial Receptivity Profile in Patients with Premature Progesterone Elevation on the Day of hCG Administration
Joint Authors
Hamamah, Samir
Dechaud, Hervé
Entezami, Frida
Assou, Said
Perrochia, Hélène
Haouzi, Delphine
Hugues, Jean-Noel
Gala, Anna
Bissonnette, Laurence
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The impact of a premature elevation of serum progesterone level, the day of hCG administration in patients under controlled ovarian stimulation during IVF procedure, on human endometrial receptivity is still debated.
In the present study, we investigated the endometrial gene expression profile shifts during the prereceptive and receptive secretory stage in patients with normal and elevated serum progesterone level on the day of hCG administration in fifteen patients under stimulated cycles.
Then, specific biomarkers of endometrial receptivity in these two groups of patients were tested.
Endometrial biopsies were performed on oocyte retrieval day and on day 3 of embryo transfer, respectively, for each patient.
Samples were analysed using DNA microarrays and qRT-PCR.
The endometrial gene expression shift from the prereceptive to the receptive stage was altered in patients with high serum progesterone level (>1.5 ng/mL) on hCG day, suggesting accelerated endometrial maturation during the periovulation period.
This was confirmed by the functional annotation of the differentially expressed genes as it showed downregulation of cell cycle-related genes.
Conversely, the profile of endometrial receptivity was comparable in both groups.
Premature progesterone rise alters the endometrial gene expression shift between the prereceptive and the receptive stage but does not affect endometrial receptivity.
American Psychological Association (APA)
Haouzi, Delphine& Bissonnette, Laurence& Gala, Anna& Assou, Said& Entezami, Frida& Perrochia, Hélène…[et al.]. 2014. Endometrial Receptivity Profile in Patients with Premature Progesterone Elevation on the Day of hCG Administration. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-510905
Modern Language Association (MLA)
Haouzi, Delphine…[et al.]. Endometrial Receptivity Profile in Patients with Premature Progesterone Elevation on the Day of hCG Administration. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-510905
American Medical Association (AMA)
Haouzi, Delphine& Bissonnette, Laurence& Gala, Anna& Assou, Said& Entezami, Frida& Perrochia, Hélène…[et al.]. Endometrial Receptivity Profile in Patients with Premature Progesterone Elevation on the Day of hCG Administration. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-510905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-510905