Immunomodulatory Effects of Danshen (Salvia miltiorrhiza) in BALBc Mice
Joint Authors
Lawrence, David A.
Gao, Donghong
Mendoza, Alvaro
Lu, Shijun
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Danshen, the root and rhizome of Salvia miltiorrhiza Bge, a Traditional Chinese Medicine, especially for cardiovascular and cerebrovascular diseases, has unique immunomodulatory effects.
Danshen is capable of anti-inflammation and antiallergy, which are immunosuppressive activities, whereas it is also able to promote immunity against cancer, viruses, and bacteria.
Most previous reports were performed with use of a purified compound or compounds of Danshen.
Since there are more than twenty active compounds in Danshen, it is very difficult to predict that one compound will act the same way when it is combined with other compounds.
In order to overcome this limitation, we used the crude form of Danshen to study its immunomodulatory effects in a mouse model.
The mice were fed daily diet supplements of Danshen for three months and then tested for their immunity, including leukocyte subsets in peripheral blood, humoral and cell-mediated immune responses, and host defenses against a Listeria monocytogenes (LM) infection.
Different doses of Danshen caused different immunomodulatory effects.
Danshen at 0.5% decreased serum IgE production in BALB/c mice; 1% Danshen promoted cell-mediated immunity; Danshen at 0.5 and 1% inhibited the production of oxygen free radicals in liver and spleen and NO production in liver; 2% Danshen enhanced the host resistance against LM with increased numbers of peripheral monocytes and natural killer (NK) cells and decreased production of IL-1β and NO.
American Psychological Association (APA)
Gao, Donghong& Mendoza, Alvaro& Lu, Shijun& Lawrence, David A.. 2012. Immunomodulatory Effects of Danshen (Salvia miltiorrhiza) in BALBc Mice. ISRN Inflammation،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-511114
Modern Language Association (MLA)
Gao, Donghong…[et al.]. Immunomodulatory Effects of Danshen (Salvia miltiorrhiza) in BALBc Mice. ISRN Inflammation No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-511114
American Medical Association (AMA)
Gao, Donghong& Mendoza, Alvaro& Lu, Shijun& Lawrence, David A.. Immunomodulatory Effects of Danshen (Salvia miltiorrhiza) in BALBc Mice. ISRN Inflammation. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-511114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511114