Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-CellHistiocyte-Rich Large B-Cell Lymphoma : A Diagnostic Challenge

Joint Authors

Gottesman, Susan R. S.
Rets, Anton V.

Source

Case Reports in Pathology

Issue

Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2014-07-07

Country of Publication

Egypt

No. of Pages

5

Main Subjects

Diseases

Abstract EN

Lymphomas with overlapping histological features of two distinct entities cause difficulty in classification.

Their classification is of particular significance when the two alternatives require different treatment modalities.

We present a diagnostically challenging case of a nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) with features of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL).

Our patient is a 39-year-old woman who presented with painless subclavicular and axillary lymphadenopathy.

The biopsied lymph node showed diffuse architectural effacement and scattered large neoplastic cells with large irregular nuclei and prominent nucleoli.

These cells were positive for CD20 and Bcl-6 and negative for CD15, CD30, IgD, and Bcl-2.

The background cells were predominantly T lymphocytes, whereas B cells were markedly depleted.

The lymph node was interpreted as NLPHL, consistent with THRLBCL-like variant.

NLPHL, especially THRLBC-like variant, and de novo THRLBCL are characterized by significant morphologic and immunophenotypic overlap.

Our case demonstrates a rare predominance of background T-cells in NLPHL and emphasizes the importance of thorough evaluation of multiple morphologic and immunophenotypic features as an essential approach for arriving at the correct diagnosis.

American Psychological Association (APA)

Rets, Anton V.& Gottesman, Susan R. S.. 2014. Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-CellHistiocyte-Rich Large B-Cell Lymphoma : A Diagnostic Challenge. Case Reports in Pathology،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-511223

Modern Language Association (MLA)

Rets, Anton V.& Gottesman, Susan R. S.. Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-CellHistiocyte-Rich Large B-Cell Lymphoma : A Diagnostic Challenge. Case Reports in Pathology No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-511223

American Medical Association (AMA)

Rets, Anton V.& Gottesman, Susan R. S.. Nodular Lymphocyte Predominant Hodgkin Lymphoma versus T-CellHistiocyte-Rich Large B-Cell Lymphoma : A Diagnostic Challenge. Case Reports in Pathology. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-511223

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-511223