System Consolidation of Spatial Memories in Mice : Effects of Enriched Environment
Joint Authors
Braschi, Chiara
Cintoli, Simona
Mastrogiacomo, Rosa
Berardi, Nicoletta
Bonaccorsi, Joyce
Pizzorusso, Tommaso
Baldanzi, Sigrid
Cenni, Maria Cristina
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Environmental enrichment (EE) is known to enhance learning and memory.
Declarative memories are thought to undergo a first rapid and local consolidation process, followed by a prolonged process of system consolidation, which consist in a time-dependent gradual reorganization of brain regions supporting remote memory storage and crucial for the formation of enduring memories.
At present, it is not known whether EE can affect the process of declarative memory system consolidation.
We characterized the time course of hippocampal and cortical activation following recall of progressively more remote spatial memories.
Wild-type mice either exposed to EE for 40 days or left in standard environment were subjected to spatial learning in the Morris water maze and to the probe test 1, 10, 20, 30, and 50 days after learning.
Following the probe test, regional expression of the inducible immediate early gene c-Fos was mapped by immunohistochemistry, as an indicator of neuronal activity.
We found that activation of the medial prefrontal cortex (mPFC), suggested to have a privileged role in processing remote spatial memories, was evident at shorter time intervals after learning in EE mice; in addition, EE induced the progressive activation of a distributed cortical network not activated in non-EE mice.
This suggests that EE not only accelerates the process of mPFC recruitment but also recruits additional cortical areas into the network supporting remote spatial memories.
American Psychological Association (APA)
Bonaccorsi, Joyce& Cintoli, Simona& Mastrogiacomo, Rosa& Baldanzi, Sigrid& Braschi, Chiara& Pizzorusso, Tommaso…[et al.]. 2013. System Consolidation of Spatial Memories in Mice : Effects of Enriched Environment. Neural Plasticity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511231
Modern Language Association (MLA)
Bonaccorsi, Joyce…[et al.]. System Consolidation of Spatial Memories in Mice : Effects of Enriched Environment. Neural Plasticity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-511231
American Medical Association (AMA)
Bonaccorsi, Joyce& Cintoli, Simona& Mastrogiacomo, Rosa& Baldanzi, Sigrid& Braschi, Chiara& Pizzorusso, Tommaso…[et al.]. System Consolidation of Spatial Memories in Mice : Effects of Enriched Environment. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511231
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511231