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Antidepressant-Like Effect of Ilex paraguariensis in Rats
Joint Authors
Busanello, Alcindo
Augusti Boligon, Aline
Libardoni, Milena
Leal, Caroline Queiroz
Lehmen, Tássia Fontana
Neto, Francisco Waldomiro Schreiner
Fachinetto, Roselei
Peroza, Luis Ricardo
Cattani, Vitória Berg
Reis, Elizete De Moraes
Athayde, Margareth Linde
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
In this study, we investigated the possible antidepressant-like effect of I.
paraguariensis in rats.
Rats were treated for four weeks with an aqueous extract of I.
paraguariensis in drinking water, following the traditional preparation of this beverage.
After the period of treatment, behavioral (elevated plus-maze, open field test, and forced swimming test) and biochemical parameters (lipid peroxidation assay, thiol content, vitamin C levels, and monoamine oxidase activity) were evaluated.
Animals were also analyzed on forced swimming test after 24 hours of I.
paraguariensis intake.
An additional group was injected with selegiline 24 hours and 30 minutes before forced swimming test as positive control.
HPLC analysis revealed the profile of I.
paraguariensis extract.
I.
paraguariensis reduced the immobility time on forced swimming test without significant changes in locomotor activity in the open field test.
Any anxiolytic/anxiogenic effect of I.
paraguariensis was observed in rats through the elevated plus-maze test.
The antidepressant-like effect of I.
paraguariensis was not accompanied by inhibitory effect on monoamine oxidase activity.
There were no significant alterations on lipid peroxidation, thiol content, and vitamin C levels among the groups.
In conclusion, aqueous extract of I.
paraguariensis decreases the time of immobility in rats suggesting an antidepressant-like effect.
American Psychological Association (APA)
Reis, Elizete De Moraes& Neto, Francisco Waldomiro Schreiner& Cattani, Vitória Berg& Peroza, Luis Ricardo& Busanello, Alcindo& Leal, Caroline Queiroz…[et al.]. 2014. Antidepressant-Like Effect of Ilex paraguariensis in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-511415
Modern Language Association (MLA)
Reis, Elizete De Moraes…[et al.]. Antidepressant-Like Effect of Ilex paraguariensis in Rats. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-511415
American Medical Association (AMA)
Reis, Elizete De Moraes& Neto, Francisco Waldomiro Schreiner& Cattani, Vitória Berg& Peroza, Luis Ricardo& Busanello, Alcindo& Leal, Caroline Queiroz…[et al.]. Antidepressant-Like Effect of Ilex paraguariensis in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-511415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511415