Reticular Basement Membrane Vessels Are Increased in COPD Bronchial Mucosa by Both Factor VIII and Collagen IV Immunostaining and Are Hyperpermeable
Joint Authors
Wood-Baker, Richard
Soltani, Amir
Muller, Hans Konrad
Walters, E. Haydn
Sohal, Sukhwinder S.
Reid, David
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Objective.
Using Collagen IV staining, we have previously reported that the reticular basement membrane (Rbm) is hypervascular and the lamina propria (LP) is hypovascular in COPD airways.
This study compared Collagen IV staining with vessels marked with anti-Factor VIII and examined vessel permeability in bronchial biopsies from COPD and normal subjects using albumin staining.
Results.
Anti-Collagen IV antibody detected more vessels in the Rbm (P=0.002) and larger vessels in both Rbm (P<0.001) and LP (P=0.003) compared to Factor VIII.
COPD airways had more vessels (with greater permeability) in the Rbm (P=0.01) and fewer vessels (with normal permeability) in the LP compared to controls with both Collagen IV and Factor VIII antibodies (P=0.04 and P=0.01).
Conclusion.
Rbm vessels were increased in number and were hyperpermeable in COPD airways.
Anti-Collagen IV and anti-Factor VIII antibodies did not uniformly detect the same vessel populations; the first is likely to reflect larger and older vessels with the latter reflecting smaller, younger vessels.
American Psychological Association (APA)
Soltani, Amir& Wood-Baker, Richard& Sohal, Sukhwinder S.& Muller, Hans Konrad& Reid, David& Walters, E. Haydn. 2012. Reticular Basement Membrane Vessels Are Increased in COPD Bronchial Mucosa by Both Factor VIII and Collagen IV Immunostaining and Are Hyperpermeable. Journal of Allergy،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511434
Modern Language Association (MLA)
Soltani, Amir…[et al.]. Reticular Basement Membrane Vessels Are Increased in COPD Bronchial Mucosa by Both Factor VIII and Collagen IV Immunostaining and Are Hyperpermeable. Journal of Allergy No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-511434
American Medical Association (AMA)
Soltani, Amir& Wood-Baker, Richard& Sohal, Sukhwinder S.& Muller, Hans Konrad& Reid, David& Walters, E. Haydn. Reticular Basement Membrane Vessels Are Increased in COPD Bronchial Mucosa by Both Factor VIII and Collagen IV Immunostaining and Are Hyperpermeable. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-511434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511434