![](/images/graphics-bg.png)
Enhanced Blood Compatibility of Metallocene Polyethylene Subjected to Hydrochloric Acid Treatment for Cardiovascular Implants
Joint Authors
Murugesan, Selvakumar
Jaganathan, Saravana Kumar
Sudheer, Theertha
Mohandas, Hemanth
Kasi, Palaniappan
Supriyanto, Eko
Sivakumar, Gunalan
Avineri Veetil, Sruthi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Blood compatibility of metallocene polyethylene (mPE) was investigated after modifying the surface using hydrochloric acid.
Contact angle of the mPE exposed to HCl poses a decrease in its value which indicates increasing wettability and better blood compatibility.
Surface of mPE analyzed by using FTIR revealed no significant changes in its functional groups after treatment.
Furthermore, scanning electron microscope images supported the increasing wettability through the modifications like pit formations and etching on the acid rendered surface.
To evaluate the effect of acid treatment on the coagulation cascade, prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured.
Both PT and APTT were delayed significantly (P<0.05) after 60 min exposure implying improved blood compatibility of the surfaces.
Hemolysis assay of the treated surface showed a remarkable decrease in the percentage of lysis of red blood cells when compared with untreated surface.
Moreover, platelet adhesion assay demonstrated that HCl exposed surfaces deter the attachment of platelets and thereby reduce the chances of activation of blood coagulation cascade.
These results confirmed the enhanced blood compatibility of mPE after HCl exposure which can be utilized for cardiovascular implants like artificial vascular prostheses, implants, and various blood contacting devices.
American Psychological Association (APA)
Jaganathan, Saravana Kumar& Mohandas, Hemanth& Sivakumar, Gunalan& Kasi, Palaniappan& Sudheer, Theertha& Avineri Veetil, Sruthi…[et al.]. 2014. Enhanced Blood Compatibility of Metallocene Polyethylene Subjected to Hydrochloric Acid Treatment for Cardiovascular Implants. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-511837
Modern Language Association (MLA)
Jaganathan, Saravana Kumar…[et al.]. Enhanced Blood Compatibility of Metallocene Polyethylene Subjected to Hydrochloric Acid Treatment for Cardiovascular Implants. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-511837
American Medical Association (AMA)
Jaganathan, Saravana Kumar& Mohandas, Hemanth& Sivakumar, Gunalan& Kasi, Palaniappan& Sudheer, Theertha& Avineri Veetil, Sruthi…[et al.]. Enhanced Blood Compatibility of Metallocene Polyethylene Subjected to Hydrochloric Acid Treatment for Cardiovascular Implants. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-511837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511837