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Periodic Distribution of a Putative Nucleosome Positioning Motif in Human, Nonhuman Primates, and Archaea : Mutual Information Analysis
Joint Authors
José, Marco V.
Li, Wentian
Mireles, Víctor
Bobadilla, Juan R.
Sosa, Daniela
Miramontes, Pedro
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-10
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Recently, Trifonov's group proposed a 10-mer DNA motif YYYYYRRRRR as a solution of the long-standing problem of sequence-based nucleosome positioning.
To test whether this generic decamer represents a biological meaningful signal, we compare the distribution of this motif in primates and Archaea, which are known to contain nucleosomes, and in Eubacteria, which do not possess nucleosomes.
The distribution of the motif is analyzed by the mutual information function (MIF) with a shifted version of itself (MIF profile).
We found common features in the patterns of this generic decamer on MIF profiles among primate species, and interestingly we found conspicuous but dissimilar MIF profiles for each Archaea tested.
The overall MIF profiles for each chromosome in each primate species also follow a similar pattern.
Trifonov’s generic decamer may be a highly conserved motif for the nucleosome positioning, but we argue that this is not the only motif.
The distribution of this generic decamer exhibits previously unidentified periodicities, which are associated to highly repetitive sequences in the genome.
Alu repetitive elements contribute to the most fundamental structure of nucleosome positioning in higher Eukaryotes.
In some regions of primate chromosomes, the distribution of the decamer shows symmetrical patterns including inverted repeats.
American Psychological Association (APA)
Sosa, Daniela& Miramontes, Pedro& Li, Wentian& Mireles, Víctor& Bobadilla, Juan R.& José, Marco V.. 2013. Periodic Distribution of a Putative Nucleosome Positioning Motif in Human, Nonhuman Primates, and Archaea : Mutual Information Analysis. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-511904
Modern Language Association (MLA)
Sosa, Daniela…[et al.]. Periodic Distribution of a Putative Nucleosome Positioning Motif in Human, Nonhuman Primates, and Archaea : Mutual Information Analysis. International Journal of Genomics No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-511904
American Medical Association (AMA)
Sosa, Daniela& Miramontes, Pedro& Li, Wentian& Mireles, Víctor& Bobadilla, Juan R.& José, Marco V.. Periodic Distribution of a Putative Nucleosome Positioning Motif in Human, Nonhuman Primates, and Archaea : Mutual Information Analysis. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-511904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511904