Health Promoting Effects of Brassica-Derived Phytochemicals : From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation
Joint Authors
Wagner, Anika Eva
Terschluesen, Anna Maria
Rimbach, Gerald
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
A high intake of brassica vegetables may be associated with a decreased chronic disease risk.
Health promoting effects of Brassicaceae have been partly attributed to glucosinolates and in particular to their hydrolyzation products including isothiocyanates.
In vitro and in vivo studies suggest a chemopreventive activity of isothiocyanates through the redox-sensitive transcription factor Nrf2.
Furthermore, studies in cultured cells, in laboratory rodents, and also in humans support an anti-inflammatory effect of brassica-derived phytochemicals.
However, the underlying mechanisms of how these compounds mediate their health promoting effects are yet not fully understood.
Recent findings suggest that brassica-derived compounds are regulators of epigenetic mechanisms.
It has been shown that isothiocyanates may inhibit histone deacetylase transferases and DNA-methyltransferases in cultured cells.
Only a few papers have dealt with the effect of brassica-derived compounds on epigenetic mechanisms in laboratory animals, whereas data in humans are currently lacking.
The present review aims to summarize the current knowledge regarding the biological activities of brassica-derived phytochemicals regarding chemopreventive, anti-inflammatory, and epigenetic pathways.
American Psychological Association (APA)
Wagner, Anika Eva& Terschluesen, Anna Maria& Rimbach, Gerald. 2013. Health Promoting Effects of Brassica-Derived Phytochemicals : From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511956
Modern Language Association (MLA)
Wagner, Anika Eva…[et al.]. Health Promoting Effects of Brassica-Derived Phytochemicals : From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-511956
American Medical Association (AMA)
Wagner, Anika Eva& Terschluesen, Anna Maria& Rimbach, Gerald. Health Promoting Effects of Brassica-Derived Phytochemicals : From Chemopreventive and Anti-Inflammatory Activities to Epigenetic Regulation. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-511956
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511956