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Maintenance Therapy with Partially Hydrolyzed Guar Gum in the Conservative Treatment of Chronic Anal Fissure : Results of a Prospective, Randomized Study
Joint Authors
Grassi, Roberto
Renzi, Adolfo
Di Martino, Natale
Iacobellis, Francesca
Brillantino, Antonio
Izzo, Giuseppe
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Purpose.
This study was designed to evaluate the role of maintenance therapy with partially hydrolyzed guar gum (PHGG) after topical application of glyceryl trinitrate (GTN) in the conservative treatment of chronic anal fissure (CAF).
Methods.
From all the patients with CAF observed during the study period, 165 subjects with healed CAF after standard therapy with topical GTN 0.4% ointment were randomized to receive (group II) or not (group I) maintenance therapy with PHGG for 10 months.
Clinical and manometric followup was carried out 6 and 12 months after treatment.
Results.
At six-month followup, median visual analogue scale score was significantly higher in group I if compared with group II.
The success and recurrence rate at 12-month followup were, respectively, 38.3% (28/73) in group I versus 58.5% (41/70) in group II (P=0.019; Fisher’s exact test) and 30.2% (13/43) in group I versus 14.5% (7/48) in group II (P=0.0047; Fisher’s exact test).
Conclusion.
The maintenance therapy with PHGG in patients with healed CAF after chemical sphincterotomy by topical application of GTN 0.4% ointment seems associated with a significant reduction of recurrence rate and with a significant increase of success rate at 12-month followup.
American Psychological Association (APA)
Brillantino, Antonio& Iacobellis, Francesca& Izzo, Giuseppe& Di Martino, Natale& Grassi, Roberto& Renzi, Adolfo. 2014. Maintenance Therapy with Partially Hydrolyzed Guar Gum in the Conservative Treatment of Chronic Anal Fissure : Results of a Prospective, Randomized Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-511995
Modern Language Association (MLA)
Brillantino, Antonio…[et al.]. Maintenance Therapy with Partially Hydrolyzed Guar Gum in the Conservative Treatment of Chronic Anal Fissure : Results of a Prospective, Randomized Study. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-511995
American Medical Association (AMA)
Brillantino, Antonio& Iacobellis, Francesca& Izzo, Giuseppe& Di Martino, Natale& Grassi, Roberto& Renzi, Adolfo. Maintenance Therapy with Partially Hydrolyzed Guar Gum in the Conservative Treatment of Chronic Anal Fissure : Results of a Prospective, Randomized Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-511995
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-511995