Refractory Uveitis in Patient with Castleman Disease Successfully Treated with Tocilizumab
Joint Authors
Oshitari, Toshiyuki
Baba, Takayuki
Itami, Makiko
Tobe, Aya
Yamamoto, Shuichi
Yotsukura, Jiro
Kajita, Fusae
Source
Case Reports in Ophthalmological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-06
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Although multicentric Castleman disease is a rare but life-threatening disease, eye complications are extremely uncommon.
We present a case of refractory uveitis accompanied with Castleman disease successfully treated with tocilizumab.
A 58-year-old man with Castleman disease was introduced for refractory uveitis to Chiba University Hospital.
Large cells were detected in the anterior chamber and increased vascular permeability of retinal vessels has been found in both eyes.
Although the patient was treated with oral and eye drop steroid treatment, the uveitis symptoms had not decreased.
The serum levels of CRP and IL-6 were increased.
The level of IL-6 concentration in the anterior chamber was the same as the serum level of IL-6.
The humanized anti-IL-6 receptor-antibody (tocilizumab) was administrated for the patient because of poor general condition.
After tocilizumab treatment, large cells in the anterior chamber were undetectable and vascular permeability was improved in FA.
The serum levels of CRP and IL-6 decreased and the general condition improved.
The side effect of tocilizumab was not observed during the treatment.
Tocilizumab treatment was significantly effective for uveitis accompanied with Castleman disease.
Although it is extremely rare, uveitis accompanied with Castleman disease may be one of the hallmarks to consider tocilizumab treatment.
American Psychological Association (APA)
Oshitari, Toshiyuki& Kajita, Fusae& Tobe, Aya& Itami, Makiko& Yotsukura, Jiro& Baba, Takayuki…[et al.]. 2012. Refractory Uveitis in Patient with Castleman Disease Successfully Treated with Tocilizumab. Case Reports in Ophthalmological Medicine،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-512186
Modern Language Association (MLA)
Oshitari, Toshiyuki…[et al.]. Refractory Uveitis in Patient with Castleman Disease Successfully Treated with Tocilizumab. Case Reports in Ophthalmological Medicine No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-512186
American Medical Association (AMA)
Oshitari, Toshiyuki& Kajita, Fusae& Tobe, Aya& Itami, Makiko& Yotsukura, Jiro& Baba, Takayuki…[et al.]. Refractory Uveitis in Patient with Castleman Disease Successfully Treated with Tocilizumab. Case Reports in Ophthalmological Medicine. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-512186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512186