Application of Genetic Algorithm for Discovery of Core Effective Formulae in TCM Clinical Data
Joint Authors
Poon, Simon
Chen, Peiqi
Sze, Daniel Man-yuen
Wang, Shaomo
Jiao, Lijing
Yang, Ming
Xu, Ling
Poon, Josiah
Cui, Lizhi
Source
Computational and Mathematical Methods in Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-30
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Research on core and effective formulae (CEF) does not only summarize traditional Chinese medicine (TCM) treatment experience, it also helps to reveal the underlying knowledge in the formulation of a TCM prescription.
In this paper, CEF discovery from tumor clinical data is discussed.
The concepts of confidence, support, and effectiveness of the CEF are defined.
Genetic algorithm (GA) is applied to find the CEF from a lung cancer dataset with 595 records from 161 patients.
The results had 9 CEF with positive fitness values with 15 distinct herbs.
The CEF have all had relative high average confidence and support.
A herb-herb network was constructed and it shows that all the herbs in CEF are core herbs.
The dataset was divided into CEF group and non-CEF group.
The effective proportions of former group are significantly greater than those of latter group.
A Synergy index (SI) was defined to evaluate the interaction between two herbs.
There were 4 pairs of herbs with high SI values to indicate the synergy between the herbs.
All the results agreed with the TCM theory, which demonstrates the feasibility of our approach.
American Psychological Association (APA)
Yang, Ming& Poon, Josiah& Wang, Shaomo& Jiao, Lijing& Poon, Simon& Cui, Lizhi…[et al.]. 2013. Application of Genetic Algorithm for Discovery of Core Effective Formulae in TCM Clinical Data. Computational and Mathematical Methods in Medicine،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-512438
Modern Language Association (MLA)
Yang, Ming…[et al.]. Application of Genetic Algorithm for Discovery of Core Effective Formulae in TCM Clinical Data. Computational and Mathematical Methods in Medicine No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-512438
American Medical Association (AMA)
Yang, Ming& Poon, Josiah& Wang, Shaomo& Jiao, Lijing& Poon, Simon& Cui, Lizhi…[et al.]. Application of Genetic Algorithm for Discovery of Core Effective Formulae in TCM Clinical Data. Computational and Mathematical Methods in Medicine. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-512438
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-512438