Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet
Joint Authors
Jewell, Kirsty
Lehner, Alexander N.
Engeham, Sarah
Austin, Ruth
Mdaki, Kennedy
Langley-Evans, Simon C.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Maternal protein restriction in rat pregnancy is associated with impaired renal development and age-related loss of renal function in the resulting offspring.
Pregnant rats were fed either control or low-protein (LP) diets, and kidneys from their male offspring were collected at 4, 13, or 16 weeks of age.
Mitochondrial state 3 and state 4 respiratory rates were decreased by a third in the LP exposed adults.
The reduction in mitochondrial function was not explained by complex IV deficiency or altered expression of the complex I subunits that are typically associated with mitochondrial dysfunction.
Similarly, there was no evidence that LP-exposure resulted in greater oxidative damage to the kidney, differential expression of ATP synthetase β-subunit, and ATP-ADP translocase 1.
mRNA expression of uncoupling protein 2 was increased in adult rats exposed to LP in utero, but there was no evidence of differential expression at the protein level.
Exposure to maternal undernutrition is associated with a decrease in mitochondrial respiration in kidneys of adult rats.
In the absence of gross disturbances in respiratory chain protein expression, programming of coupling efficiency may explain the long-term impact of the maternal diet.
American Psychological Association (APA)
Engeham, Sarah& Mdaki, Kennedy& Jewell, Kirsty& Austin, Ruth& Lehner, Alexander N.& Langley-Evans, Simon C.. 2012. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513959
Modern Language Association (MLA)
Engeham, Sarah…[et al.]. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-513959
American Medical Association (AMA)
Engeham, Sarah& Mdaki, Kennedy& Jewell, Kirsty& Austin, Ruth& Lehner, Alexander N.& Langley-Evans, Simon C.. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513959