Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet
المؤلفون المشاركون
Jewell, Kirsty
Lehner, Alexander N.
Engeham, Sarah
Austin, Ruth
Mdaki, Kennedy
Langley-Evans, Simon C.
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Maternal protein restriction in rat pregnancy is associated with impaired renal development and age-related loss of renal function in the resulting offspring.
Pregnant rats were fed either control or low-protein (LP) diets, and kidneys from their male offspring were collected at 4, 13, or 16 weeks of age.
Mitochondrial state 3 and state 4 respiratory rates were decreased by a third in the LP exposed adults.
The reduction in mitochondrial function was not explained by complex IV deficiency or altered expression of the complex I subunits that are typically associated with mitochondrial dysfunction.
Similarly, there was no evidence that LP-exposure resulted in greater oxidative damage to the kidney, differential expression of ATP synthetase β-subunit, and ATP-ADP translocase 1.
mRNA expression of uncoupling protein 2 was increased in adult rats exposed to LP in utero, but there was no evidence of differential expression at the protein level.
Exposure to maternal undernutrition is associated with a decrease in mitochondrial respiration in kidneys of adult rats.
In the absence of gross disturbances in respiratory chain protein expression, programming of coupling efficiency may explain the long-term impact of the maternal diet.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Engeham, Sarah& Mdaki, Kennedy& Jewell, Kirsty& Austin, Ruth& Lehner, Alexander N.& Langley-Evans, Simon C.. 2012. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet. Journal of Nutrition and Metabolism،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513959
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Engeham, Sarah…[et al.]. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet. Journal of Nutrition and Metabolism No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-513959
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Engeham, Sarah& Mdaki, Kennedy& Jewell, Kirsty& Austin, Ruth& Lehner, Alexander N.& Langley-Evans, Simon C.. Mitochondrial Respiration Is Decreased in Rat Kidney Following Fetal Exposure to a Maternal Low-Protein Diet. Journal of Nutrition and Metabolism. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-513959
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-513959
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر