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Rapid Quantification of Ethyl Carbamate in Spirits Using NMR Spectroscopy and Chemometrics
Joint Authors
Monakhova, Yulia B.
Lachenmeier, Dirk W.
Kuballa, Thomas
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-19
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Ethyl carbamate (EC, urethane, C2H5OCONH2) is a genotoxic carcinogen and is regularly found in fermented food products including alcoholic beverages.
In this study, the rapid method of nuclear magnetic resonance (NMR) spectroscopy in combination with partial least squares (PLS) regression is applied for the first time to the analysis of ethyl carbamate in stone fruit spirits (n=119) and unrecorded alcohols (n=27) (analysis time only 15 min per sample).
The PLS procedure was validated using an independent set of samples (n=43, R2=0.89, RMSE=0.14 mg/L) in comparison to reference GC/MS/MS results.
The NMR method was found to outperform other screening techniques based on NIR or FTIR regarding sensitivity and selectivity.
The major advantage over GC/MS/MS, besides the reduced time of instrumental analysis, is that no sample preparation besides addition of buffer with internal standard is required, while for GC/MS/MS labour-intensive sample extraction is necessary prior to measurement.
American Psychological Association (APA)
Monakhova, Yulia B.& Kuballa, Thomas& Lachenmeier, Dirk W.. 2012. Rapid Quantification of Ethyl Carbamate in Spirits Using NMR Spectroscopy and Chemometrics. ISRN Analytical Chemistry،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513972
Modern Language Association (MLA)
Monakhova, Yulia B.…[et al.]. Rapid Quantification of Ethyl Carbamate in Spirits Using NMR Spectroscopy and Chemometrics. ISRN Analytical Chemistry No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-513972
American Medical Association (AMA)
Monakhova, Yulia B.& Kuballa, Thomas& Lachenmeier, Dirk W.. Rapid Quantification of Ethyl Carbamate in Spirits Using NMR Spectroscopy and Chemometrics. ISRN Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-513972
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-513972