Serum levels of adhesion molecules in lichen planus and the effect of associated hepatitis C virus
Other Title(s)
مستوى الجزيئات اللاصقة في المصل في مرض الحزاز المنبسط تأثير مصاحبة الفيروس الكبدي "سي"
Joint Authors
Ahmad, Suhayr Muhammad
Mubashir, Ala al-Din Abd al-Al
Mahmud, Ahmad Muhammad
Source
Issue
Vol. 26, Issue 3 (31 Jul. 2002), pp.35-42, 8 p.
Publisher
Assiut University Faculty of Medicine
Publication Date
2002-07-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Topics
Abstract EN
Immunological mechanisms have been suggested to be fundamental in the initiation and perpetuation of lichen planus (LP).
Adhesion molecules such as ICAM-1, VCAM-I and E-selectin, play an important role in immune cell interaction.
LP has recently been observed to occur with increased frequency in patients with hepatitis C virus.
So the aim of this work is to measure serum levels of ICAM-1, VCAM-I and E-selectin in LP patients and to compare the levels of these adhesion molecules in LP patients associated with and without HCV.
Serum levels of slCAM-1, sVCAM-1 andsE-selectin were measured by ELISA in 48 LP patients (38 classic and 10 actinic) and 24 healthy controls.
Both patients and controls were screened for hepatitis C virus antibodies by ELISA technique.
Serum levels of sICAM-1, sVCAM-1 and sE-selectin were significantly higher in LP patients compared to controls (P< 0.05, 0.01 and 0.001 respectively).
Only sE-selectin was significantly higher in actinic patients compared to patients with classical LP(P< 0.05).
There were no significant difference in the studied parameters between patients with and without mucus membrane affection.
Hepatitis C associated LP patients (15=31%) had significantly higher levels of sICAM-1 and sVCAM-1 compared to hepatitis C negative patients (P < 0.001 and 0.05 respectively).
No significant difference in the levels ofsE-selectin was found between the two groups.
Adhesion molecules, may play an important role in the pathogenesis of lichen planus, with a distinct role of hepatitis C virus on ICAM-l.
American Psychological Association (APA)
Mubashir, Ala al-Din Abd al-Al& Ahmad, Suhayr Muhammad& Mahmud, Ahmad Muhammad. 2002. Serum levels of adhesion molecules in lichen planus and the effect of associated hepatitis C virus. Assiut Medical Journal،Vol. 26, no. 3, pp.35-42.
https://search.emarefa.net/detail/BIM-56541
Modern Language Association (MLA)
Ahmad, Suhayr Muhammad…[et al.]. Serum levels of adhesion molecules in lichen planus and the effect of associated hepatitis C virus. Assiut Medical Journal Vol.26, No.3(July, 2002), pp.35-42.
https://search.emarefa.net/detail/BIM-56541
American Medical Association (AMA)
Mubashir, Ala al-Din Abd al-Al& Ahmad, Suhayr Muhammad& Mahmud, Ahmad Muhammad. Serum levels of adhesion molecules in lichen planus and the effect of associated hepatitis C virus. Assiut Medical Journal. 2002. Vol. 26, no. 3, pp.35-42.
https://search.emarefa.net/detail/BIM-56541
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 42
Record ID
BIM-56541