The role of interleukine-33 in inflammatory bowel disease
Joint Authors
Hwaydi, Raghad R.
al-Khazraji, Khalid A. Jasim
Abbas, Ahmad A.
Source
al-Kindy College Medical Journal
Issue
Vol. 10, Issue 2 (31 Dec. 2014), pp.14-18, 5 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : The inflammatory bowel disease (IBD), Crohn’s disease (CD) and ulcerative colitis (UC) are heterogenous chronic inflammatory disorders of the gastrointestinal tract.
The most widely accepted etiopathogenic hypothesis for these disorders suggests an immune mediated process.
Objective : This study was performed to evaluate the role of interleukine-33 in pathogenesis of inflammatory bowel disease and to correlate their levels with the disease activity and/or severity.
Methods : Fifty five subjects with inflammatory bowel disease (41 ulcerative colitis patients and 14 Crohn’s disease patients) their ages range from 16-65 years and 25 apparently healthy volunteers their ages and sexes were matched with the patients were participated in this study.
Blood samples were collected from all patients and controls to assess serum concentrations of interleukine-33 by enzyme-linked immune-sorbent assay.
Results : The present data revealed that there was significant elevation (P < 0.
05) in serum levels of interleukine-33 in ulcerative colitis and Crohn’s disease patients as compared with control group.
Concerning the correlation between serum levels of interleukine-33 with clinical parameters, the current study revealed a positive correlation between serum interleukine-33 with the disease activity in ulcerative colitis (P = 0.
41).
As regards to disease location, interleukine-33 was significantly higher (P < 0.
001) in ulcerative colitis patients with pan-colitis (E3) as compared to those patients with proctitis disease (E1) and CD of the colon (E2).
Conclusion : This study indicated that interleukine-33 might be a crucial mediator in the pathogenesis of inflammatory bowel disease
American Psychological Association (APA)
Hwaydi, Raghad R.& Abbas, Ahmad A.& al-Khazraji, Khalid A. Jasim. 2014. The role of interleukine-33 in inflammatory bowel disease. al-Kindy College Medical Journal،Vol. 10, no. 2, pp.14-18.
https://search.emarefa.net/detail/BIM-580734
Modern Language Association (MLA)
Hwaydi, Raghad R.…[et al.]. The role of interleukine-33 in inflammatory bowel disease. al-Kindy College Medical Journal Vol. 10, no. 2 (2014), pp.14-18.
https://search.emarefa.net/detail/BIM-580734
American Medical Association (AMA)
Hwaydi, Raghad R.& Abbas, Ahmad A.& al-Khazraji, Khalid A. Jasim. The role of interleukine-33 in inflammatory bowel disease. al-Kindy College Medical Journal. 2014. Vol. 10, no. 2, pp.14-18.
https://search.emarefa.net/detail/BIM-580734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 18
Record ID
BIM-580734