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Serum levels of ghrelin, adipokines, and tumor necrosis factor-a (Tnf-a) in patients with juvenile idiopathic arthritis in Assuit University Hospitals : relation to nutritional status and disease activity
Joint Authors
Salim, Zahra I.
Monzea, Iman M. M.
Sharif, Tahra Muhammad Kamil Sad al-Din
Abd al-Aziz, Nafisah H. R.
Source
Egyptian Pediatric Association Gazette
Issue
Vol. 63, Issue 2 (30 Jun. 2015), pp.52-57, 6 p.
Publisher
Egyptian Pediatric Association
Publication Date
2015-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background: In juvenile idiopathic arthritis (JIA) several proinflammatory cytokines are secreted leading to anorexia and weight loss.
Objectives: We aimed to measure serum levels of ghrelin, adipocytokines and tumor necrosis factor alpha (TNF-a) in JIA patients.
Also, to correlate them with disease activity and patients’ body mass index (BMI).
Patients and methods: Sixty-five patients with JIA (40 girls and 25 boys; means ±SD of age were 12.1 ±3.5 years) and 54 matched healthy controls were evaluated by ELISA to measure levels of ghrelin, leptin, adiponectin and TNF-a and correlate these levels with Juvenile Arthritis Disease Activity Score (JADAS) and patients’ BMI.
Results: Thirty-four patients (52.3%) had active disease while 31 (47.7%) had inactive disease.
JIA patients had significantly lower level of ghrelin and leptin and significantly higher level of TNF-a than the control group (P 6 0.001, P 6 0.05, P 6 0.001, respectively).
Those with active disease had significantly lower level of ghrelin and significantly higher TNF-a level than those with inactive disease (P 6 0.001, P 6 0.01, respectively).
Significant positive correlations were
American Psychological Association (APA)
Salim, Zahra I.& Abd al-Aziz, Nafisah H. R.& Sharif, Tahra Muhammad Kamil Sad al-Din& Monzea, Iman M. M.. 2015. Serum levels of ghrelin, adipokines, and tumor necrosis factor-a (Tnf-a) in patients with juvenile idiopathic arthritis in Assuit University Hospitals : relation to nutritional status and disease activity. Egyptian Pediatric Association Gazette،Vol. 63, no. 2, pp.52-57.
https://search.emarefa.net/detail/BIM-591933
Modern Language Association (MLA)
Salim, Zahra I.…[et al.]. Serum levels of ghrelin, adipokines, and tumor necrosis factor-a (Tnf-a) in patients with juvenile idiopathic arthritis in Assuit University Hospitals : relation to nutritional status and disease activity. Egyptian Pediatric Association Gazette Vol. 63, no. 2 (Jun. 2015), pp.52-57.
https://search.emarefa.net/detail/BIM-591933
American Medical Association (AMA)
Salim, Zahra I.& Abd al-Aziz, Nafisah H. R.& Sharif, Tahra Muhammad Kamil Sad al-Din& Monzea, Iman M. M.. Serum levels of ghrelin, adipokines, and tumor necrosis factor-a (Tnf-a) in patients with juvenile idiopathic arthritis in Assuit University Hospitals : relation to nutritional status and disease activity. Egyptian Pediatric Association Gazette. 2015. Vol. 63, no. 2, pp.52-57.
https://search.emarefa.net/detail/BIM-591933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 56-57
Record ID
BIM-591933