Serum fructosamine measurement as an index of glycaemic state in Iraqi diabeties

Abstract EN

Objective : To determine the usefulness of measuring serum fructosamine (gtycosyiated protein) as an index of assessment of glycaemic state.

Design : ?respective study of the glycaemic state of diabetic patiente over a period of 6 months from 1st January 1996 to 30th June 1996.

Setting: Diabetic €linic of hlosul Teaching Hospital.

Participants : A total of 340 individuals including 60 presumably type 1 diabetics (41 males, 19 females, aged 12-51 years), 180 type 2 diabetics (85 males, 95 females, aged 28-65 years) and 100 healthy subjects (59 males, 41 females, aged 19-60 years) Main outcome measures : Measures were fasting plasnia glucose and serum fructosamine levels.

Correction of fructosamine concentration according to albumin level was performed.

Student's unpaired t-test and linear regression analysis were used for data evaluation.

Main Results: The distribution of fructosamine in the control group showed a normal Gaussian pattern with the reference range calculated as mean ± 2SD was 1.50-2.50 mmol/1.

Serum fructosamine was significantly higher in type 1 and type 2 diabetics in comparison with control group (P < 0.001).

A significant correlation was observed betw'een plasma glucose and serum fructosamine in type I (r = 0.?18), type 2 (r = 0.868) and control group (٢ = 0.814)(P < 0.001).

Agreement between glucose and fructosamine was noted in 81.7 % of cases with type 1 and 90.5 % of 'cases with type 2 diabetes.

When measured fructosamine was corrected according to serum albumin, a highly significant correlation was observed between measured and corrected values in diabetics with type 1 (r = 0.996), type 2 (r = 0.995) and non-diabetics (r = 0.951) (P < 0.001).

Conclusion : Serum fructosamine presents a suitable index for the evaluation and monitoring of glycaemic control particularly in those with unstable diabetes.

Correction of measured values for albumin concentration seems to be unnecessary particularly in those with normal protein status.