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Low dose tadalafil effect on anthropometric and metabolic parameters in Iraqi diabetic obese men
Author
Source
al-Kindy College Medical Journal
Issue
Vol. 10, Issue 2 (31 Dec. 2014), pp.91-95, 5 p.
Publisher
University of Baghdad al-Kindi College of Medicine
Publication Date
2014-12-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Abstract EN
Background: Phosphodiesterase-5 (PDE-5) inhibitors restore nitric oxide (NO) signaling and may reduce circulating inflammatory markers, and improve metabolic parameters through a number of mechanisms.
Daily administration of the PDE-5 inhibitor, tadalafil (TAD) may attenuate inflammation; improve fasting plasma glucose and triglyceride levels and body weight.
This study aims to evaluate the efficacy of low dose PDE-5 inhibitor, tadalafil (TAD) in controlling dysglycemia and body weight in obese diabetic men.
Methods: Forty obese men with type 2 diabetes aged 30-50 years incorporated in this study, all with A1c of 7-8.5%, attending obesity unit in AL-Kindy college of medicine.
Weight, height, BMI, FPG, A1c, cholesterol, TG, HDL and LDL measured for all and advised for low calories diet and increasing exercise and randomized into 2 groups , first (control) without and the second (therapy) with addition of tadalafil 2.5mg/day for 8 weeks, then remeasure all the parameters after.
Results blotted in tables and statistical analysis done using SPSS program and t-test.
Results: There was significant reduction in weight, BMI, FPG, cholesterol, TG and LDL, while no significant change in A1c , and although there was elevation in HDL but was insignificant in control group.
In therapy group both weight, BMI, FPG, A1c, cholesterol, TG, and LDL show significant reduction, with mild insignificant elevation in HD.
When compare the results of both groups significant results appear in percentage of change of FPG and A1c in therapy group.
Conclusion: Low calories diet and exercise are effective in reducing obesity parameters in type 2 diabetes, in addition, improve dysglycemia and dyslipidemia , adding tadalafil 2.5mg/day can add beneficial effect specifically for FPG and A1c significantly
American Psychological Association (APA)
Khazal, Faris A.. 2014. Low dose tadalafil effect on anthropometric and metabolic parameters in Iraqi diabetic obese men. al-Kindy College Medical Journal،Vol. 10, no. 2, pp.91-95.
https://search.emarefa.net/detail/BIM-624939
Modern Language Association (MLA)
Khazal, Faris A.. Low dose tadalafil effect on anthropometric and metabolic parameters in Iraqi diabetic obese men. al-Kindy College Medical Journal Vol. 10, no. 2 (2014), pp.91-95.
https://search.emarefa.net/detail/BIM-624939
American Medical Association (AMA)
Khazal, Faris A.. Low dose tadalafil effect on anthropometric and metabolic parameters in Iraqi diabetic obese men. al-Kindy College Medical Journal. 2014. Vol. 10, no. 2, pp.91-95.
https://search.emarefa.net/detail/BIM-624939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 94-95
Record ID
BIM-624939