Association between polycystic ovary syndrome and genetic polymorphisms of CYP 17 gene in Iraqi women
Joint Authors
Muhammad, Marwah B.
Umran, Mahfuzah A.
al-Awadi, Salwa Jabir Abd Allah
Source
Iraqi Journal of Biotechnology
Issue
Vol. 14, Issue 2 (31 Dec. 2015), pp.99-110, 12 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
12
Main Subjects
Topics
Abstract EN
Polycystic ovary syndrome (PCOS), whose genetic basis is not completely well understood, it is the most common endocrine disorder in women in their reproductive years.
Blood samples were col-lected from two groups.
The first group included 61 females with PCOS and the second group included 30 normal females to detect the presence of mutation in the CYP17 gene.
The two groups were genotyped and a comparison was done between them.
The results showed a significant difference (p<0.05) in FSH levels in patients and normal females and there is no significant difference in the levels of Testosterone, prolactin and LH.
Moreover, it showed a significant difference (p<0.05) in the levels of HDL in both pa-tients and normal females and no significant difference in the levels of (LDL, VLDL, Triglyceride and cholesterol).
Two comparisons for genotype were done: one between age and genotype and the second between BMI and genotype for each group.
The results showed two types of genotype, which were a TT wild type and a heterozygote TC mutant type.
Furthermore, the results showed a significant difference (p<0.05) in genotype TT and TC in the group of age less than 25 years old and no significant difference in these genotypes in age groups (25-35) and those with more than 35 years old.
It is concluded from this study that this single nucleotide polymorphism in the CYP 17 gene was not associated with PCOS in Iraqi women.
American Psychological Association (APA)
Muhammad, Marwah B.& al-Awadi, Salwa Jabir Abd Allah& Umran, Mahfuzah A.. 2015. Association between polycystic ovary syndrome and genetic polymorphisms of CYP 17 gene in Iraqi women. Iraqi Journal of Biotechnology،Vol. 14, no. 2, pp.99-110.
https://search.emarefa.net/detail/BIM-644807
Modern Language Association (MLA)
Muhammad, Marwah B.…[et al.]. Association between polycystic ovary syndrome and genetic polymorphisms of CYP 17 gene in Iraqi women. Iraqi Journal of Biotechnology Vol. 14, no. 2 (2015), pp.99-110.
https://search.emarefa.net/detail/BIM-644807
American Medical Association (AMA)
Muhammad, Marwah B.& al-Awadi, Salwa Jabir Abd Allah& Umran, Mahfuzah A.. Association between polycystic ovary syndrome and genetic polymorphisms of CYP 17 gene in Iraqi women. Iraqi Journal of Biotechnology. 2015. Vol. 14, no. 2, pp.99-110.
https://search.emarefa.net/detail/BIM-644807
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 108-110
Record ID
BIM-644807