Protective effects of caffeic acid on quinolinic acid-induced behavioral and oxidative alterations in rats
Joint Authors
Ali, Sayyid F.
Colın Gonzalez, Ana Laura
De Lima, Maria Eduarda
Chavarrıa, Anahı
Villeda, Juana
Santamarıa, Abel
Sanchez-Hernandez, Sayyid
Source
Journal of Drug and Alcohol Research
Issue
Vol. 4, Issue 2015 (31 Dec. 2015), pp.1-5, 5 p.
Publisher
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Study design.
The protective effects of the natural antioxidant caffeic acid (CA) on behavioral tasks and lipid peroxidation were tested in an excitotoxic model produced by unilateral intrastriatal injection of quinolinic acid (QUIN), and in striatal slices incubated in the presence of the same toxin.
CA (20mg/kg) was administered intraperitoneally to rats every day for five days; then, rats received QUIN (240 nmol/μL).
Six days later, motor asymmetry was quantified by the preferential use of forelimbs and the circling behavior tests.
Rat striatal slices (300 μm thick) were incubated in the presence of CA (30–300 μM) and/or QUIN (100 μM) to estimate oxidative stress.
Results.
QUIN induced motor asymmetry in lesioned rats and increased lipid peroxidation in striatal slices when compared to control values.
CA prevented the QUIN-induced toxic endpoints in a concentrationdependent manner.
Conclusion.
Our results support the neuroprotective role of CA in neurotoxic paradigms recruiting excitotoxic events
American Psychological Association (APA)
Colın Gonzalez, Ana Laura& Sanchez-Hernandez, Sayyid& De Lima, Maria Eduarda& Ali, Sayyid F.& Chavarrıa, Anahı& Villeda, Juana…[et al.]. 2015. Protective effects of caffeic acid on quinolinic acid-induced behavioral and oxidative alterations in rats. Journal of Drug and Alcohol Research،Vol. 4, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-654722
Modern Language Association (MLA)
Colın Gonzalez, Ana Laura…[et al.]. Protective effects of caffeic acid on quinolinic acid-induced behavioral and oxidative alterations in rats. Journal of Drug and Alcohol Research Vol. 4 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-654722
American Medical Association (AMA)
Colın Gonzalez, Ana Laura& Sanchez-Hernandez, Sayyid& De Lima, Maria Eduarda& Ali, Sayyid F.& Chavarrıa, Anahı& Villeda, Juana…[et al.]. Protective effects of caffeic acid on quinolinic acid-induced behavioral and oxidative alterations in rats. Journal of Drug and Alcohol Research. 2015. Vol. 4, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-654722
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5
Record ID
BIM-654722