Topical application of tranexamic acid versus systemic injection during coronary artery bypass graft surgery : a comparative study
Joint Authors
Kamali, Ayman M.
Siyam, Ilham A.
al-Nahas, Yasir M.
Abd al-Aziz, Abd al-Aziz A.
Masud, Amr M.
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 8, Issue 4 (31 Dec. 2015), pp.479-482, 4 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Topics
Abstract EN
Background Diffuse microvascular bleeding remains a common problem after myocardial revascularization with cardiopulmonary bypass.
Objectives The effi cacy of locally administered tranexamic acid (topical application) was compared with systemically administered tranexamic acid to reduce postoperative bleeding after cardiopulmonary bypass in elective nonredo coronary artery bypass grafting ( CABG).
Methods The study included 60 patients of both sexes, aged between 35 and 65 years, and scheduled for elective CABG; patients were randomly assigned to two groups: group I (the intravenous tranexamic acid group; 30 patients) and group II (the topical tranexamic acid group; 30 patients).
For each patient in each group, postoperative blood loss, number of units of packed red blood cells (RBCs) and fresh frozen plasma ( FFP) transfused, frequency of resternotomy, duration of hospital and ICU stay, and mortality were recorded.
Results There were statistically signifi cant differences between the two groups with regard to total postoperative blood loss and need for packed RBCs and FFP transfusion, being much greater in group I than in group II.
There was no mortality in either group.
Frequency of resternotomy was higher in group I than in group II, although the difference was statistically nonsignifi cant.
The duration of hospital and ICU stay revealed no statistically signifi cant differences between the two groups.
Conclusion Intraoperative topical administration of tanexamic acid into the pericardial cavity before sternal closure during CABG surgery has reduced the incidence of postoperative blood loss and the need for postoperative packed RBCs and FFP transfusion.
American Psychological Association (APA)
Siyam, Ilham A.& Kamali, Ayman M.& al-Nahas, Yasir M.& Abd al-Aziz, Abd al-Aziz A.& Masud, Amr M.. 2015. Topical application of tranexamic acid versus systemic injection during coronary artery bypass graft surgery : a comparative study. Ain Shams Journal of Anesthesiology،Vol. 8, no. 4, pp.479-482.
https://search.emarefa.net/detail/BIM-655164
Modern Language Association (MLA)
Siyam, Ilham A.…[et al.]. Topical application of tranexamic acid versus systemic injection during coronary artery bypass graft surgery : a comparative study. Ain Shams Journal of Anesthesiology Vol. 8, no. 4 (Oct. / Dec. 2015), pp.479-482.
https://search.emarefa.net/detail/BIM-655164
American Medical Association (AMA)
Siyam, Ilham A.& Kamali, Ayman M.& al-Nahas, Yasir M.& Abd al-Aziz, Abd al-Aziz A.& Masud, Amr M.. Topical application of tranexamic acid versus systemic injection during coronary artery bypass graft surgery : a comparative study. Ain Shams Journal of Anesthesiology. 2015. Vol. 8, no. 4, pp.479-482.
https://search.emarefa.net/detail/BIM-655164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 482
Record ID
BIM-655164