Does intrathecal midazolam improve hyperbaric bupivacaine-fentanyl anesthesia in elderly patients ?
Joint Authors
Boules, Majid L.
Ubayd, Riham S.
Ali, Muhammad Z.
Samhan, Yasir M.
Source
Ain Shams Journal of Anesthesiology
Issue
Vol. 8, Issue 4 (31 Dec. 2015), pp.602-607, 6 p.
Publisher
Ain Shams University Faculty of Medicine Department of Anesthesiology
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Objective To assess the effect of intrathecal midazolam with bupivacaine–fentanyl in elderly patients undergoing endourologic procedures.
Materials and methods This prospective, randomized, double-blind study involved 60 ASA physical status II-III patients aged over 60 years scheduled for elective endoscopic urologic procedures under spinal anesthesia with hyperbaric bupivacaine 0.5% (5 mg/ml).
They were randomized into one of three equal groups of 20 patients each: the fi rst group, control group (group C), received 7.5 mg hyperbaric bupivacaine 0.5% in a volume of 1.5 ml; the second group, fentanyl group (group F), received 7.5 mg hyperbaric bupivacaine 0.5% in a volume of 1.5 ml and 10 μg fentanyl (0.1 ml); and the third group, fentanylmidazolam group (group FM), received 7.5 mg hyperbaric bupivacaine 0.5% in a volume of 1.5 ml and 10 μg fentanyl (0.1 ml) plus 1.0 mg of midazolam (0.2 ml).
Sensory and motor effects were assessed.
Postoperative pain, sedation, and adverse effects were also recorded.
Results The three studied groups were comparable in demographic and clinical characteristics.
They were hemodynamically stable.
There was no signifi cant difference between the three groups in the onset of sensory (P = 0.721) and motor block (P = 0.342), duration of motor block (P = 0.286), and sedation score (P = 0.229).
Duration of sensory block was prolonged in group F compared with the control group (P < 0.001) and prolonged more in group FM compared with the F group (P = 0.065).
Time to fi rst request of rescue analgesic was signifi cantly longer in group F compared with the C group (P = 0.033) and in FM compared with the F group (P < 0.001).
All patients reported excellent or good degree of satisfaction with anesthetic procedure (P = 0.547).
Conclusion Adjuvant intrathecal midazolam resulted in intraoperative hemodynamic stability and safely potentiates postoperative analgesic effect of bupivacainefentanyl spinal anesthesia in elderly patients undergoing endourologic procedures.
American Psychological Association (APA)
Ubayd, Riham S.& Ali, Muhammad Z.& Boules, Majid L.& Samhan, Yasir M.. 2015. Does intrathecal midazolam improve hyperbaric bupivacaine-fentanyl anesthesia in elderly patients ?. Ain Shams Journal of Anesthesiology،Vol. 8, no. 4, pp.602-607.
https://search.emarefa.net/detail/BIM-655286
Modern Language Association (MLA)
Ubayd, Riham S.…[et al.]. Does intrathecal midazolam improve hyperbaric bupivacaine-fentanyl anesthesia in elderly patients ?. Ain Shams Journal of Anesthesiology Vol. 8, no. 4 (Oct. / Dec. 2015), pp.602-607.
https://search.emarefa.net/detail/BIM-655286
American Medical Association (AMA)
Ubayd, Riham S.& Ali, Muhammad Z.& Boules, Majid L.& Samhan, Yasir M.. Does intrathecal midazolam improve hyperbaric bupivacaine-fentanyl anesthesia in elderly patients ?. Ain Shams Journal of Anesthesiology. 2015. Vol. 8, no. 4, pp.602-607.
https://search.emarefa.net/detail/BIM-655286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 606-607
Record ID
BIM-655286