Amelioration of cisplatin-induced nephrotoxicity by ethanolic extract of bauhinia purpurea : an in vivo study in rats
Joint Authors
Rana, Azmat
Nasir al-Din, Muhammad
Khan, Ijaz Ahmad
Khan, Rahat Ali
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 27, Issue 1 (29 Feb. 2016), pp.41-48, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2016-02-29
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
Our objective is to study the nephroprotective activity and antioxidant potential of Bauhinia purpurea unripe pods and bark against cisplatin-induced nephrotoxicity.
Healthy adult albino rats of either sex (150-200 g) were randomly divided into six groups of six animals each- Group I (vehicle control) and Group II (negative control).
Group III (BBE200) and Group IV (BBE400) were administered the ethanolic extract of Bauhinia purpurea bark in doses of 200 and 400 mg/kg/day p.o., respectively, and Group V (BPE200) and Group VI (BPE400) were administered the ethanolic extract of Bauhinia purpurea unripe pods at doses of 200 and 400 mg / kg/day p.o., respectively.
All the treatments were given for nine days.
Cisplatin in a single dose of 6 mg/kg i.p.
was given on the 4th day to all groups, except the vehicle control group.
On the 10th day, blood and urine were collected for biochemical tests and the rats were sacrificed.
The kidney was removed for histology and lipid peroxidation–antioxidant test.
Cisplatin caused nephrotoxicity as evidenced by elevated blood urea, serum creatinine and urine glucose, and there was decreased creatinine clearance in Group II as compared with Group I.
Administration of BBE and BPE at doses of 200 and 400 mg/kg in Group III and Group VI caused a dose-dependant reduction in the rise of blood urea, serum creatinine and urine glucose, and there was a dosedependant increase in creatinine clearance compared with Group II.
There was increased catalase and glutathione and decreased malondialdehyde levels in Group II, while BBE 400 (Group IV) and BPE 400 (Group VI) treatments significantly reversed the changes toward normal values.
Histological examination of the kidney revealed protection in Group IV and Group VI compared with Group II.
The ethanolic extract of Bauhinia purpurea unripe pods and bark has a nephroprotective activity against cisplatin-induced nephrotoxicity in rats.
American Psychological Association (APA)
Rana, Azmat& Khan, Rahat Ali& Nasir al-Din, Muhammad& Khan, Ijaz Ahmad. 2016. Amelioration of cisplatin-induced nephrotoxicity by ethanolic extract of bauhinia purpurea : an in vivo study in rats. Saudi Journal of Kidney Diseases and Transplantation،Vol. 27, no. 1, pp.41-48.
https://search.emarefa.net/detail/BIM-655833
Modern Language Association (MLA)
Khan, Ijaz Ahmad…[et al.]. Amelioration of cisplatin-induced nephrotoxicity by ethanolic extract of bauhinia purpurea : an in vivo study in rats. Saudi Journal of Kidney Diseases and Transplantation Vol. 27, no. 1 (Jan. / Feb. 2016), pp.41-48.
https://search.emarefa.net/detail/BIM-655833
American Medical Association (AMA)
Rana, Azmat& Khan, Rahat Ali& Nasir al-Din, Muhammad& Khan, Ijaz Ahmad. Amelioration of cisplatin-induced nephrotoxicity by ethanolic extract of bauhinia purpurea : an in vivo study in rats. Saudi Journal of Kidney Diseases and Transplantation. 2016. Vol. 27, no. 1, pp.41-48.
https://search.emarefa.net/detail/BIM-655833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 47-48
Record ID
BIM-655833