مقايسة مستويات الأضداد الذاتية للبروتين الكابح للورم p53 لدى مرضى سرطان رئة في سورية
Other Title(s)
Measurement of p53 auto-antibodies levels in lung cancer patients in Syria
Joint Authors
شفيق مراد
عطايا، عبود
الصالح، جمانة
Source
Issue
Vol. 6, Issue 9 (30 Apr. 2013), pp.77-84, 8 p.
Publisher
Syrian Clinical Laboratory Association
Publication Date
2013-04-30
Country of Publication
Syria
No. of Pages
8
Main Subjects
Topics
Abstract EN
Background: p53 mutations are the most common genetic mutations in human cancer, and mutated p53 protein was found to induce p53 Auto-antibodies in sera of patients with various types of cancers, serum p53-Abs measurement may be useful for detection mutant p53 gene.
AIM: Measure p53-Abs in sera from lung cancer patients, and evaluate its correlation to following clinical parameters: gender, smoking, histopathology classification of tumor and staging classification of tumor.
Methods: serum samples from 92 patients with lung cancer and 34 healthy individuals were collected between 2008-2010, patients admitted to the 3 main hospitals in Damascus (ALMouasat, ALAsad and ALMujtahd).
p53-Abs levels were measured by sandwich ELISA (Biodiagnostic, Germany).
Results: p53-Abs were detected in 16/92 (17.4%) lung cancer patients, whereas none of the healthy group sera were positive for p53-Abs, the difference was statistically significant (P=0.009).
There was no significant correlation between the presence of p53-Abs and each of: gender (P=0.96), smoking (p=0.65), histopathology classification of tumor (Small Cell Lung Cancer SCLC or Non Small Cell Lung Cancer NSCLC) (p=0.22), staging classification of SCLC (Limited Disease LD or Extensive Disease ED) (p=0.21).
The presence of p53-Abs was significantly higher in Adenocarcinoma NSCLC patients, in comparison to Squamous Carcinoma NSCLC patients (p=0.04), the presence of p53-Abs was significantly higher in Advanced NSCLC (Stage III, IV), in comparison to Early NSCLC (Stage I, II) (P=0.45).
Conclusion: p53-Abs can be used as Serological tumor marker for lung cancer screening and for early diagnosis
American Psychological Association (APA)
شفيق مراد وعطايا، عبود والصالح، جمانة. 2013. مقايسة مستويات الأضداد الذاتية للبروتين الكابح للورم p53 لدى مرضى سرطان رئة في سورية. مجلة التشخيص المخبري،مج. 6، ع. 9، ص ص. 77-84.
https://search.emarefa.net/detail/BIM-656789
Modern Language Association (MLA)
شفيق مراد....[و آخرون]. مقايسة مستويات الأضداد الذاتية للبروتين الكابح للورم p53 لدى مرضى سرطان رئة في سورية. مجلة التشخيص المخبري مج. 6، ع. 9 (نيسان 2013)، ص ص. 77-84.
https://search.emarefa.net/detail/BIM-656789
American Medical Association (AMA)
شفيق مراد وعطايا، عبود والصالح، جمانة. مقايسة مستويات الأضداد الذاتية للبروتين الكابح للورم p53 لدى مرضى سرطان رئة في سورية. مجلة التشخيص المخبري. 2013. مج. 6، ع. 9، ص ص. 77-84.
https://search.emarefa.net/detail/BIM-656789
Data Type
Journal Articles
Language
Arabic
Notes
يتضمن مراجع ببليوجرافية : ص. 83-84
Record ID
BIM-656789