Biological evaluation of potent antioxidant, lipoxygenase inhibitor and antibacterial : a comparative study

Abstract EN

Three biologically active new Schiff bases, 2-[(3-hydroxybenzylidene)amino]phenol 5, 2- [(4-hydroxybenzylidene)amino]phenol 6 and 4-[(2-hydroxyphenylimino)methyl]benzene-1,3-diol 7, were synthesized by the reaction of 2-aminophenol 1 with three different hydroxyl-benzaldehydes 2–4.

They were characterized by spectroscopic analysis (IR, 1H NMR, EI-MS) along with elemental analyses.

The products were biological screened out for antioxidant, lipoxygenase inhibition, antibacterial and urease inhibition activities.

The compounds 5 and 6 showed potent while 7 showed moderate antioxidant activity.

Compound 6 showed potent whereas 5 and 7 showed significant lipoxygenase inhibition activity.

All the target compounds showed excellent activities against Staphylococcus intermedius, Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Salmonella typhi bacteria.

All the compounds showed non-significant activity against urease enzyme.