Non-invasive predictors of portal hypertension in patients with hepatitis C virus related hepatocellular carcinoma
Joint Authors
Mahran, Zakariyya Y.
Saqr, Muhammad
al-Baz, Ahmad
Barakat, Iman
Abu al-Muti, Muhammad
Abd al-Hamid, Muhammad
Source
Journal of the Egyptian Society of Parasitology
Issue
Vol. 45, Issue 3 (31 Dec. 2015), pp.545-554, 10 p.
Publisher
The Egyptian Society of Parasitology
Publication Date
2015-12-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
The reference standard for portal venous pressure measurement which is clinically important for estimating the feasibility of resection of hepatocellular carcinoma is the hepatic venous pressure gradient, which is invasive and expensive.
The present study evaluated the noninvasive parameters for assessment of portal hypertension in Child A patients with hepatocellular carcinoma on top of hepatitis C virus.
A total of 112 patients were subjected to clinical assessment, biochemical assay, ultrasonographic Doppler study, triphasic spiral abdominal computed tomography, upper gastrointestinal endoscopy and hepatic venous pressure gradient measurement.
According to hepatic venous pressure gradient measurement, they were classified into groups: GI: 58 patients with hepatic venous pressure gradient <10 mmHg and GII: 54 patients with hepatic venous pressure gradient ≥ 10 mmHg.
Significant variables in univariate analysis were included in a multivariate analysis to establish a model for prediction of clinically significant portal hypertension.
Results showed that portal vein diameter ≥ 1.3 cm, mono or biphasic pattern of flow in hepatic veins and Giannini index ≤ 909 were independent risk factors for the clinically significant portal hypertension as indicated by HVPG ≥ 10 mmHg.
A model with highest likelihood ratio and good fitness was created.
This prediction model was displayed by the receiver operating characteristic curve and under the curve area was 0.969 (0.938-1).
American Psychological Association (APA)
Mahran, Zakariyya Y.& Saqr, Muhammad& Barakat, Iman& al-Baz, Ahmad& Abd al-Hamid, Muhammad& Abu al-Muti, Muhammad. 2015. Non-invasive predictors of portal hypertension in patients with hepatitis C virus related hepatocellular carcinoma. Journal of the Egyptian Society of Parasitology،Vol. 45, no. 3, pp.545-554.
https://search.emarefa.net/detail/BIM-668959
Modern Language Association (MLA)
Mahran, Zakariyya Y.…[et al.]. Non-invasive predictors of portal hypertension in patients with hepatitis C virus related hepatocellular carcinoma. Journal of the Egyptian Society of Parasitology Vol. 45, no. 3 (Dec. 2015), pp.545-554.
https://search.emarefa.net/detail/BIM-668959
American Medical Association (AMA)
Mahran, Zakariyya Y.& Saqr, Muhammad& Barakat, Iman& al-Baz, Ahmad& Abd al-Hamid, Muhammad& Abu al-Muti, Muhammad. Non-invasive predictors of portal hypertension in patients with hepatitis C virus related hepatocellular carcinoma. Journal of the Egyptian Society of Parasitology. 2015. Vol. 45, no. 3, pp.545-554.
https://search.emarefa.net/detail/BIM-668959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 552-554
Record ID
BIM-668959