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Interleukine-6 level in saliva of patients with chronic Periodontitis : a case-control study
Author
Source
Journal of Baghdad College of Dentistry
Issue
Vol. 28, Issue 1 (31 Mar. 2016), pp.103-108, 6 p.
Publisher
University of Baghdad College of Dentistry
Publication Date
2016-03-31
Country of Publication
Iraq
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background:Periodontal diseases are infectious diseases in which periodontalpathogens trigger chronic inflammatory and immune responses.
Interleukine-6 is a multifunctional cytokine playing a central role in inflammation and tissue injury.The aim of the study IS to determine the level of Interleukin-6(IL-6) in saliva of patients with chronic periodontitis compared to healthy subjects.
Materials and Methods:The total subjects of the present study is 60, divided into 3 groups; 20 patients with chronic periodontitis with pocket depth(PD ≥4 mm)(group I), 20 patients with pocket depth(PD <4 mm) with clinical attachment loss (group II), and 20 healthy controls with pocket probing depth (PPD ≤ 3 mm) without clinical attachment loss (group III).
Un-stimulated salivary sample was taken from each subject and was investigated for the presence of Interleukine-6by using Enzyme‑linked Immunosorbent Assay (ELISA) technology.
Results:Mean IL-6 levels in saliva in patients with chronic periodontitis (98.40 ± 18.44 ng/L)was significantly higher than in controls (11.67 ± 3.32; p=0.001).
Also a significant difference in IL-6 levels in saliva was observed between the PPD ≥ 4 mm and PPD < 4 mm groups and between PPD ≥ 4 mm and control groups, as well as statistically significant differences were observed between PPD < 4 mm and control groups (P < 0.001).
Conclusion:The Interleukine-6 level in saliva can be considered as one of inflammatory biomarker indicators of severity of periodontitis.
American Psychological Association (APA)
Nanakaly, Haween T.. 2016. Interleukine-6 level in saliva of patients with chronic Periodontitis : a case-control study. Journal of Baghdad College of Dentistry،Vol. 28, no. 1, pp.103-108.
https://search.emarefa.net/detail/BIM-683418
Modern Language Association (MLA)
Nanakaly, Haween T.. Interleukine-6 level in saliva of patients with chronic Periodontitis : a case-control study. Journal of Baghdad College of Dentistry Vol. 28, no. 1 (Mar. 2016), pp.103-108.
https://search.emarefa.net/detail/BIM-683418
American Medical Association (AMA)
Nanakaly, Haween T.. Interleukine-6 level in saliva of patients with chronic Periodontitis : a case-control study. Journal of Baghdad College of Dentistry. 2016. Vol. 28, no. 1, pp.103-108.
https://search.emarefa.net/detail/BIM-683418
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 107-108
Record ID
BIM-683418